摘要
目的探讨黄芪对荷瘤小鼠的抑瘤作用及抑瘤机理。方法将50只昆明种小鼠随机分为阴性对照组、阳性对照组、低剂量组、中剂量组、高剂量组。复制荷瘤小鼠模型后,阴性对照组给予生理盐水、阳性对照组给予环磷酰胺,其余三个组给予不同剂量黄芪多糖。观察抑瘤率、T淋巴细胞增殖反应、NK细胞毒活性等指标。结果(1)随着黄芪剂量增加,抑瘤率逐渐增加(P<0.05);(2)使用黄芪的三个不同剂量实验组的T淋巴细胞增殖反应、NK细胞毒活性均高于阴性对照组(P<0.05),且随着剂量的增加,以上指标有逐渐增加的趋势。结论黄芪多糖可通过增强小鼠细胞免疫水平起到抑制肿瘤的作用。
OBJECTIVE The aim of this study was to explore the effect of Astragalus polysacchari(APS) on anti-tumor in the mice with tumor and its mechanism of anti-tumor.METHODS Fifty mice were divided into five groups randomly: negative group,positive group,low dose group,median dose group and high dose group respectively.After the mice model with tumor were constructed,the mice in negative group were given normal saline the mice in positive group were given cyclophosphamide,the other experimental groups were given different dose of ASP.The parameters of tumor inhibited rate,proliferative T cell responses,cytotoxicity of NK cell were observed.RESULTS (1) With the dose of ASP increased,tumor inhibited rate became higher and higher(P<0.05).(2) The parameters of proliferative T cell responses,cytotoxicity of NK cell of the three experimental group were higher than those of the positive group.Moreover,in the three experimental groups,with the dose becoming high,the two parameters increased.CONCLUSION Asp could inhibit the tumor in mice through the way of strengthening the level cell immunity.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2008年第z2期686-688,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
黄芪多糖
肿瘤
Astragalus polysacchari
tumor
