摘要
建立器官免疫耐受是维持移植器官长期存活的理想境界。目前,在临床上应用的诱导免疫耐受的方案主要有:建立混合嵌合体;应用阻断共刺激通路的抗体;删除T细胞[1]。其中建立嵌合体是诱导器官免疫耐受的重要途径。本文就嵌合体的概念、种类、建立嵌合体的方法及其诱导免疫耐受的机理,嵌合体的检测及临床应用的研究进展作一综述。
The establishment of immune tolerance to organ transplant is to maintain long-term survival of Utopia. At present, the clinical application of immune tolerance induced by the program include: the establishment of mixed chimerism; application of costimulatory pathway blocking antibodies; removal of T-cell. Which is a chimera immune tolerance induced organ an important way. This paper includes the following aspects: the concept of chimerism, type, methods and the establishment of the mechanism of immune toler...
出处
《当代医学》
2008年第14期25-26,共2页
Contemporary Medicine
关键词
器官移植
免疫耐受
嵌合体
organ transplantation
immune tolerance
chimerism
