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Twist在胃癌黏膜组织的表达及在上皮间质转化中的作用 被引量：5

Expression of Twist in gastric cancer and its role in epithelial-mesenchymal transition
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摘要 目的:观察上皮间质转化因子Twist在胃癌中的表达情况以及与胃癌恶性生物学行为的相关性。方法:采用免疫组化SP法检测59例胃癌组织中Twist,上皮源性标记物E-cadherin,间叶源性标记物Vimentin的表达,并分析与各临床病理因素之间的关系。结果:59例胃癌组织中Twist阳性表达率为74.6%(44/59),29例观察到E-cadherin表达的降低,同时7例观察到Vimentin表达上调。Twist的表达与淋巴结转移密切相关(P<0.05);而且Twist表达与E-cadherin表达降低(P<0.05)和Vimentin的表达上调(P<0.05)之间都存在相关性。结论:Twist可能通过调控上皮间质转化从而在胃癌的侵袭转移过程中发挥作用。 Objective:To investigate the expression of epithelial-mesenchymal transition(EMT) related markers Twist in gastric carcinoma tissues and its relation with the malignant features.Methods:The expression of Twist,E-cadherin and Vimentin proteins in 59 cases of gastric cancer tissues was detected by using immunohistochemistry and compared with clinicopathological data.Results:Twist was detected in 44 cases(74.6%) of gastric cancer.The expression of E-cadherin was reduced in 29 cases and Vimentin was up-regulate...
作者 冯美燕 宁晓明 刘婷 耿敬姝
机构地区 哈尔滨医科大学附属肿瘤医院病理科
出处 《现代肿瘤医学》 CAS 2008年第11期1949-1952,共4页 Journal of Modern Oncology
基金 黑龙江省自然科学基金(编号:D2005-11) 哈医大附属肿瘤医院基金(编号:JJ2007-08)
关键词 胃癌 TWIST E-CADHERIN 上皮间质转化 转移 gastric cancer Twist E-cadherin EMT metastasis
分类号 R735.2 [医药卫生—肿瘤]
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参考文献15

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同被引文献39

  • 1姚婵,来茂德.上皮间质转化(EMT)及其分子机制[J].国际遗传学杂志,2006,29(4):290-294. 被引量：25
  • 2封明轩,骆明德,费哲为,欧敬民,李建,李宁.TGF-β1长期诱导胰腺癌细胞发生上皮间质变而增加其侵袭性[J].现代肿瘤医学,2007,15(6):766-768. 被引量：10
  • 3徐静,陈孝平,向秋.原发性肝癌Twist基因表达的研究[J].中华肿瘤防治杂志,2007,14(13):994-996. 被引量：9
  • 4Russ HA,Ravassard P,Kerr-Conte J,et al.Epithelialmesenchymal transition in cells expanded in vitro from lineagetraced adult human pancreatic beta cells[J].PLoS One,2009,4(7):6417.
  • 5Carlson BM.胚胎学基础[M].6版.北京:中国协和医科大学出版社,2002:469-484.
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  • 7冯晓莉,何群,陆敏,等译.泌尿系统及男性生殖器官肿瘤病理学及遗传学[M].北京:人民卫生出版社,2006:176.
  • 8Yang J, Mani SA, Donaher JL, et al. Twist, a master regulator of mor- phogenesis, plays an essential role in tumor metastasis[ J ]. Cell,2004, 117(7) :927-939.
  • 9Valsesia-Wittmann S, Magdeleine M, Dupasquier S, et al. Oncogenic cooperation between H-Twist and N-My ooverrides failsafe program in cancer ceils[ J]. Cancer Cell ,2004,6(2 ) :625-630.
  • 10Signoretti S,Di Marcotultio L, Richardson L, et al. Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer [ J ]. J Clin Inves,2002,110(5 ) :633-641.

引证文献5

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现代肿瘤医学
2008年 第11期

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