摘要
目的根据帕金森病(Parkinso disease,PD)可能的发病机制,探讨PD的临床综合治疗方法。方法对服用美多巴一年以上的30例老年PD给予加服叶酸、甲钴胺治疗半年,加服前及加服后半年分别测定血浆同型半胱氨酸(Hcy)并进行Webster修订记分法评分,比较治疗前后的差异。结果在原有抗帕金森治疗基础上经过加服叶酸和甲钴胺治疗半年,血浆Hcy水平由治疗前(14.531±5.212)mol/L降为治疗后(11.920±4.742)mol/L。治疗前后差异有统计学意义(P<0.05)。Webster修订记分法评分十项中,有手部动作过缓、僵直、步态、震颤、言语和生活自理能力等六项经过半年治疗后均达到了有统计学意义的改善(P<0.01或P<0.05)。结论降低血浆Hcy水平,补充叶酸和甲钴胺可能是PD的又一治疗方向。
Objective To investigate the clinical comprehensive treatment of Parkinson s disease(PD)based on the possible nosogenesis of the disease.Methods 30 PD cases of senior people who have been taking madopar tablets over one year are enrolled in this research.The patients blood homocysteine is measured and their behaviors are scored using modified Webster Parkinson scale before and half year after they are given folacin and mecobalamin.The differences between before and after taking extra medicine are analysed....
出处
《福建医药杂志》
CAS
2008年第6期7-9,共3页
Fujian Medical Journal
关键词
帕金森病
同型半胱氨酸
治疗分析
叶酸
甲钴胺
Parkinson s disease（PD）
Homocysteine
Treatment analysis
Folacin
Mecobalamin
