摘要
目的探讨糖尿病周围神经病变(DPN)的相关危险因素。方法收集254例2型糖尿病患者的年龄、体质指数、腰臀比、糖尿病病程、血压、空腹血糖、餐后2h血糖、糖化血红蛋白、血脂、胰岛B细胞功能等临床资料。根据神经传导速度(NCV)将患者分为DPN组(144例)和非DPN组(110例)。对有统计学意义的危险因素行多因素Logistic回归分析,筛选DPN的危险因素。结果DPN组的年龄、糖尿病病程、收缩压、糖化血红蛋白水平均显著高于非DPN组(P值均<0.01)。多因素Logistic回归分析提示,年龄(OR=1.051,95%CI为1.018~1.085,P=0.002)、糖尿病病程(OR=1.059,95%CI为1.008~1.113,P=0.022)和糖化血红蛋白(OR=1.183,95%CI为1.060~1.319,P=0.003)是DPN的危险因素。结论DPN的发生与患者的年龄、糖尿病病程和糖化血红蛋白增高有关,代谢因素在其发病机制中起重要作用,是DPN的独立危险因素。
Objective To study the risk factors for diabetic peripheral neuropathy (DPN). Methods The clinical data of 254 patients with type 2 diabetes, including the age, body mass index (BMI), waist/hip radio (WHR), course of diabetes, blood pressure, fasting plasma glucose (FPG), 2 h postprandial plasma glucose (2 hPG), HbA1c, lipid and islet B cell function were collected. The patients were divided into 2 groups according to the nerve conduction velocity (NCV): DPN group (144 cases) and non-DPN group (110 cases). ...
出处
《上海医学》
CAS
CSCD
北大核心
2008年第10期721-723,共3页
Shanghai Medical Journal
