摘要
目的探讨COX-2、VEGF和MMP-9在人胃癌组织中的表达及临床意义。方法应用免疫组化SABC法检测45例人胃癌组织中COX-2、VEGF和MMP-9的表达,并以30例正常胃黏膜组织作为对照。对COX-2、VEGF和MMP-9的表达采用平均光密度测定,并对临床相关资料进行统计学分析。结果胃癌组织中COX-2、VEGF和MMP-9的平均光密度值(OD)为(19.85±7.34)、(134.67±13.11)和(18.81±7.56)显著高于正常胃黏膜组织的表达[(12.49±4.87)、(83.89±8.74)和(11.46±4.82),P<0.01],癌组织中COX-2、VEGF和MMP-9的表达与性别、年龄、部位、组织类型、分化程度无相关性,而与肿瘤直径、TNM分期、淋巴转移、远处转移相关(P<0.05),同时经相关性分析发现在胃癌组织中,COX-2与VEGF和MMP-9表达有显著相关性(γ=0.473,P=0.005,γ=0.437,P=0.001),而VEGF与MMP-9之间无相关性(γ=0.142,P=0.467>0.05)结论COX-2可能诱导VEGF和MMP-9的表达而促进肿瘤血管的生成和侵袭转移。
Objective To study the expression of cyclooxygenase-2(COX-2), endothelial growth factor(VEGF) Matrix Metallo-Proteinase-9(MMP-9) in gastric carcinoma and it′s possible clinical significance.MethodsThe expression of COX-2, VEGF and MMP-9 were studied by immunohistochemistry SABC method in 45 gastric carcinoma specimen and 30 normal gastric tissues as control.The average light density was assayed by the expression of COX-2, VEGF and MMP-9, and the statistic software was used to analyze the clinical correlated...
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第21期3202-3206,共5页
China Journal of Modern Medicine
关键词
胃癌
COX-2
VEGF
MMP-9
gastric carcinoma
cyclooxygenase-2
vascular endothelial growth factor
matrix metallo proteinase-9
