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普罗布考对颈动脉硬化症的抗氧化和抗炎症作用 被引量：3

The anti-oxidation and anti-inflammation effects of probucol in the patients with carotid atherosclerosis disease
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摘要 目的:观察口服普罗布考对颈动脉硬化症患者氧化低密度脂蛋白(ox-LDL)及血清炎性指标水平的变化,探讨普罗布考对颈动脉硬化症的抗氧化、抗炎症作用。方法:将72例颈动脉硬化症患者随机分为两组:普罗布考组38例,在常规药物治疗的基础上口服普罗布考片0.5g,2次/d,持续12周;对照组34例,常规药物治疗,不服用任何调脂药物及抗氧化剂。分别于治疗前后检测血清ox-LDL、高敏C反应蛋白(hs-CRP)、白细胞介素-lβ(IL-lβ)、基质金属蛋白酶-9(MMP-9)水平及血脂系列等。结果:普罗布考组治疗后总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、ox-LDL、hs-CRP、IL-lβ、MMP-9显著下降(P<0.05);对照组治疗后上述指标均无显著变化。治疗后两组间TC、LDL-C、ox-LDL、hs-CRP、IL-lβ、MMP-9差异有统计学意义(P<0.05)。结论:普罗布考可降低颈动脉硬化症患者的TC、LDL-C、ox-LDL、hs-CRP、IL-lβ和MMP-9水平,并具有一定程度的抗氧化和抑制动脉粥样硬化慢性炎症过程的作用。 Objective To investigate the anti-oxidation and anti-inflammation effects of probucol in the patients with carotid atherosclerosis disease by measuring plasma cholesterol,oxidized low density lipoprotein(ox-LDL)and inflammation parameters before and after treatment.Methods:72 patients were divided into treatment group(n=38)and control group(n=34).Patients in the treatment group took probucol besides the routine therapy.The total treatment phase was 12 weeks.Patients in the control group only took the routin...
作者 侯晓强 薛飞 袁建新 李壬子
机构地区 华北煤炭医学院附属开滦医院神经内科
出处 《陕西医学杂志》 CAS 北大核心 2008年第12期1614-1616,1668,共4页 Shaanxi Medical Journal
关键词 颈动脉疾病/药物疗法 @普罗布考 C反应蛋白质/血液 脂蛋白类 LDL/血液 白细胞介素1/血液 Carotid artery diseases/drug therapy @Probucol C-Reactive protein/blood Lipoproteins LDL/blood Interleukin-1/blood
分类号 R543 [医药卫生—心血管疾病]
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参考文献7

  • 1[1]Shah PK.Link between infection and atherosclerosis:who are the culprits:viruses,baeteria,both,or neither? Circulation,2001,103(1):5-6.
  • 2[2]Yokoyama T,Miyauchi K,Kurata T,et al.Effect of probucol on neointimal thickening in a stent porcine restenosis model.Jpn Heart J,2004,45(2):305-313.
  • 3[3]Doggrell SA.Immunomodulation with DiNAC-a new approach to the treatment of atherosclerosis? Expert Opin Investig Drugs,2002,11(5).717-720.
  • 4傅琛,夏强,曹春梅,高琴,姚慧,金红峰.活性氧、NO和线粒体ATP敏感钾通道在TNF-α预处理对缺血/再灌注心肌保护中的作用[J].中国应用生理学杂志,2005,21(1):20-24. 被引量：14
  • 5[6]Zwaka TP,Hombach V,Torzewski J.C-reactive protein mediated low density lipoprotein uptake by macrophages implications for atherosclerosis.Circulation,2001,103 (9):1194-1197.
  • 6[7]Liu GX,Ou DM,Li LX,et al.Probucol inhibits oxidized-low density lipoprotein-induced adhesion of monocytes to endothelial cells in vitro.Acta Pharmacol Sin,2002,23(6):516-522.
  • 7[8]Niemann-Jonsson A,Dimayuga P,Jovinge S,et al.Accumulation of LDL in rat arteries is associated with activation of tumor necrosis factor-alpha expression.Arterioscler Thromb Vase Biol,2000,20(10):2205-2211.

二级参考文献9

  • 1Chandel N S,Maltepe E, Goldwasser E, et al. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription[J]. Proc Natl Acad Sci USA, 1998, 95(20): 11715-11720.
  • 2Goldhaber J I, Kim K H, Natterson P D, et al. Effects of TNF-alpha on[Ca2+]i and contractility in isolated adult rabbit ventricular myocytes[J]. Am J Physiol, 1996, 271(4 Pt 2): H1449-H1455.
  • 3Hoshida S, Kuzuya T, Fuji H, et al. Sublethal ischemia alters myocardial antioxidant activity in canine heart[J]. Am J Physiol, 1993,264(1 Pt 2): H33-H39.
  • 4Rogers R J, Monnier J M, Nick H S. Tumor necrosis factor-alpha selectively induces Mn-SOD expression via mitochondria-to-nucleus signaling,whereas interleukin-1 beta utilizes an alternative pathway[J]. J Biol Chem, 2001, 276(23): 20419-20427.
  • 5Yamashita N, Hoshida S, Otsu K,et al. Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation[J]. J Exp Med, 1999, 189(11): 1699-1706.
  • 6Shiono N, Rao V, Weisel R D, et al. L-arginine protects human heart cells from low-volume anoxia and reoxygenation[J]. Am J Physiol Heart Circ Physiol, 2002, 282(3): H805-H815.
  • 7Yaguchi Y, Satoh H, Wakahara N, et al. Protective effects of hydrogen peroxide against ischemia/reperfusion injury in perfused rat hearts[J]. Circ J, 2003, 67(3): 253-258.
  • 8Lebuffe G, Schumacker P T, Shao Z H, et al. ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel[J]. Am J Physiol Heart Circ Physiol, 2003, 284(1): H299-H308.
  • 9Bell R M, Maddock H L, Yellon D M. The cardioprotective and mitochondrial depolarising properties of exogenous nitric oxide in mouse heart[J]. Cardiovasc Res, 2003, 57(2): 405-415.

共引文献13

同被引文献47

引证文献3

二级引证文献44

陕西医学杂志
2008年 第12期

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