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2型糖尿病血浆抵抗素与大血管并发症的关系 被引量:1

Relationship Between Plasma Concentrations of Resistin and Type 2 Diabetes Mellitus with Macroangiopathies
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摘要 目的探讨抵抗素在2型糖尿病患者大血管并发症中的作用。方法利用彩色多普勒超声技术观察60例2型糖尿病患者颈动脉内中膜厚度及斑块的变化,依据颈动脉超声结果将其分为3组:IMT<0.8mm为内膜正常组,0.8mm≤IMT<1mm为内膜增厚组,IMT≥1mm和/或发现有斑块形成者为斑块形成组。检测2型糖尿病患者血浆抵抗素、IMT及相关实验参数,并与30名正常对照组进行比较。结果糖尿病各组血浆抵抗素含量均较对照组显著升高(P<0.01),斑块形成组抵抗素水平明显高于内膜正常组(P<0.01);多元线性相关分析显示:年龄、HOMA-IR、IMT与抵抗素显著正相关;多元逐步回归分析表明:抵抗素为IMT有显著意义的决定因素。结论2型糖尿病大血管并发症患者存在较高的抵抗素水平,血浆抵抗素在2型糖尿病大血管并发症中起重要作用。 Objective To investigate the effect of plasma concentrations of resistin on type 2 diabetes mellitus(T2DM) with macroangiopathies.Method Color Doppler ultrasound was used to measure the intima-media thickness(IMT) and plaque of the common carotid artery in 60 cases of T2DM.The patients were assigned to three groups based on IMT:the group with normal IMT(IMT<0.8mm);the group with thicker IMT(0.8mm≤ IMT<1mm);the group with plaque(IMT≥1mm).Fasting plasma resistin,IMT and the related experimental paramete...
出处 《中国血液流变学杂志》 CAS 2008年第4期526-528,共3页 Chinese Journal of Hemorheology
关键词 抵抗素 糖尿病 大血管病变 Resistin Diabetes mellitus Macroangiopathy
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