摘要
目的:分析400例胸腔积液的病因分布特点,探讨胸水及血清肿瘤标记物检测对鉴别良恶性胸腔积液的意义。方法:分析400例胸腔积液住院患者的临床资料,采用化学发光免疫法检测胸水及血清中的CEA、CA125、CA199水平并进行统计分析。结果:400例胸腔积液中,良性233例(58.3%),其中主要以结核为主,共144例(61.8%),其次为肺炎39例(16.7%),心功能不全19例(8.2%),脓胸11例(4.7%),其他20例(8.5%)。恶性胸液156例(39%),原发性支气管肺癌131例(84%),乳腺癌6例(3.8%),其他恶性肿瘤19例(12.1%),不明原因者11例(2.7%)。41～59岁之间恶性胸液占该年龄组的42.3%。胸液中肿瘤标记物CEA、CA125、CA199水平恶性组高于良性组(P<0.01)。结论:结核和肿瘤是导致胸腔积液的主要原因,能否尽快鉴别二者直接影响其治疗和预后。41～59岁之间恶性胸液的发生率占该年龄组42.3%,应该引起重视。胸水中CEA、CA125、CA199三项指标联合检测,对恶性胸腔积液的敏感度为96.2%,特异度为91.7%,准确度为93.8%。联合检测CEA,CA125,CA199对鉴别良恶性胸腔积液有较高的临床价值。
Objective:To analysis the cause of pleural effusion,discuss the significance of serum and effusion tumor marker in differentiate diagnosis of pleural effusion.Methods:The clinical cases of 400 hospitalized patients with pleural effusion were reviewed and their CEA,CA125,CA199 levels in serum and pleural effusion were detected.Results:Out of the 400 pleural effusion,233 were cases were benign(58.3%),144 cases of which were tuberculosis(61.8%),39 cases were Pneumonia(16.7%)and 19 cases were cardiac insufficie...
出处
《华西医学》
CAS
2008年第6期1321-1323,共3页
West China Medical Journal
