摘要
40只大鼠分为4组(n=10):正常对照组、自发性高血压大鼠组、膳食纤维低剂量组(5%)、膳食纤维高剂量组(10%)。经裙带菜膳食纤维处理8w后,检测离体血管的内皮依赖性舒张效应、尾动脉收缩压、血浆一氧化氮(NO)水平,并用Western印迹检测内皮型一氧化氮合酶(eNOS)蛋白表达水平,发现裙带菜可溶性膳食纤维显著降低尾动脉收缩压,显著改善内皮功能及血浆NO的水平并伴随着eNOS蛋白表达水平的上调。这些结果表明,裙带菜膳食纤维能降低自发性高血压大鼠的尾动脉收缩压,这可能与增加NO的产生来改善其内皮功能有关。
40 rats were divided into 4 groups(n=10) as control group,spontaneous hypertension rat(SHR) group,low dose dietary fiber-treated group(5%),and high dose dietary fiber-treated group(10%).After 8 weeks of treatment,the endothelium-dependent vasorelaxation in isolated aortic rings,systolic pressure of tail artery and content of plasma nitric oxide(NO) were determined.The protein expression of endothelial NO synthase(eNOS) was measured by using Western blot.It was found that Undaria pinnatifida dietary fiber tr...
出处
《食品科学》
EI
CAS
CSCD
北大核心
2009年第3期267-269,共3页
Food Science
基金
湖南农业大学动物医学院基金项目(BK0717)
湖南农业大学青年基金项目(04QN03)
关键词
裙带菜
膳食纤维
一氧化氮
内皮型一氧化氮合酶
大鼠
Undaria pinnatifida
dietary fiber
nitric oxide
endothelial nitric oxide synthase
rat
