摘要
目的:探讨益肾活血胶囊与动脉粥样硬化斑块稳定性的关系。方法:将32只载脂蛋白E基因敲除(apoE-KO)小鼠随机分为对照(C)组,益肾活血胶囊大、小剂量(YSHXH、YSHXL)组,辛伐他汀(S)组,应用ELISA法测定小鼠血清oxLDL,油红O(oil-red O)染色观察斑块内脂质含量,应用免疫组化法测定巨噬细胞在斑块内的浸润水平。结果:YSHXH组及S组与C组比较血清oxLDL显著下降(3.91±2.62 vs 3.90±2.63 vs 16.07±5.50μg/ml,P<0.01),斑块内脂质含量明显减少,巨噬细胞浸润明显降低。YSHXL组与C组比较上述指标没有明显差异(P>0.05)。结论:大剂量益肾活血胶囊能降低apoE-KO小鼠血清oxLDL,减少斑块内脂质含量,减少巨噬细胞在斑块内的浸润,对动脉粥样硬化斑块具有稳定作用。
Objective: To investigate the effects of Yishen Huoxue(YSHX)capsule on serum oxLDL and the stabili-ty of atherosclerotic plaque.Methods:Apolipoprotein E-knockout mice were divided into contro(lC)group,YSHX capsule high dose(YSHXH)group,YSHX capsule low dose(YSHXL)group,Simvastatin(S)group.The amount of serum oxLDL was determined by ELISA,lipid in atherosclerotic plaque was determined by oil-red O staining,the expressions of macrophage in the plaque was determined by immunohistochemistry.Results: Serum oxLDL...
出处
《山东中医药大学学报》
2009年第1期55-57,共3页
Journal of Shandong University of Traditional Chinese Medicine
基金
国家自然科学基金资助课题(编号:30572452)
