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三维适形放射治疗局部晚期NSCLC近期疗效观察 被引量:1

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摘要 目的探讨三维适形后程逐步递量加速放射治疗局部晚期非小细胞肺癌(NSCLC)的近期疗效和急性放射反应。方法将56例局部晚期NSCLC放疗患者随机分为常规剂量三维适形组(A组)26例,和后程逐步递量加速组(B组)30例。采用6MV-X线照射,首程常规三维适形放疗,2.0 Gy/次,5次/周,至DT=40 Gy后重新CT扫描制定计划,B组后程改为分别2.3 Gy/次,2.6 Gy/次,3.0 Gy/次,照射3次,5次/周,总剂量61.4 Gy。照射野包括胸部CT可见的原发灶以及纵隔≥1.0 cm单个或成束淋巴结。A组1例,B组2例,因不能耐受放弃治疗。结果按计划完成放疗病例的近期疗效:A组总有效率72.0%(18/25),B组总有效率78.6%(22/28);A、B 2组发生放射性食管炎分别为19例、17例和放射性肺炎分别为18例、19例。结论后程逐步递量加速放射治疗NSCLC近期疗效满意,放射反应相当,是对放射治疗NSCLC的有益尝试,但远期疗效和并发症仍有待大样本验证。
出处 《中国厂矿医学》 2009年第1期35-36,共2页 Chinese Medicine of Factory and Mine
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