摘要
目的观察血管紧张素受体阻滞剂坎地沙坦的降压疗效和对心功能的影响。方法试验组(n=36),口服坎地沙坦8mg,1次/d,连用4周;对照组(n=36)口服卡托普利12.5mg,2次/d或3次/d,连用4周,用药期间仔细体格检查,给药前后行超声心动图计算射血分数(EF)和E/A比值,评定心功能变化。结果试验组SBP和DBP都有明显降低,而对照组改变不明显,2组间比较差异非常显著;2组治疗后心功能都有明显改善,试验组总有效率为83.33%,对照组为69.44%,2组比较差异有显著性;2组治疗后LVEF均升高:试验组32.6±2.3vs40.9±2.5(P<0.05),对照组31.9±3.1vs37.5±2.9(P<0.05);E/A比值升高:试验组0.52±0.03vs0.94±0.11(P<0.05),对照组0.54±0.05vs0.72±0.10,试验组好转更明显。结论坎地沙坦有利于缓解心力衰竭症状,改善其收缩功能和舒张功能;其疗效优于卡托普利。
Objective To observe the efficacy and effect on heart failure of candesartan.Method 72 ypertensive patients with CHF(congestive heart failure)were divided to receive candesartan 8 mg daily(n=36)for 4 weeks or oral captopril 12.5 mg 2~3 times daily(n=36)for 4 weeks.Pre-treatment and post-treatment physical examination,EF(ejectionfraction)and E/A ratio were performed during treatment.Results The SBP and DBP were significantly decreased in the active group but not in the control group.The geart function were s...
出处
《中国现代药物应用》
2009年第4期18-19,共2页
Chinese Journal of Modern Drug Application
关键词
高血压
充血性心力衰竭
坎地沙坦
Hypertension
Congestiveheartfailure
Candeirbesartan
