摘要
目的:观察5-氟尿嘧啶(5-Fu)和草酸铂联合时辰化疗治疗晚期大肠癌的临床疗效和毒性反应。方法:83例晚期大肠癌患者随机分为A组(时辰化疗组,41例)和B组(常规化疗组,42例)。所有患者行5-氟尿嘧啶(5-Fu,700mg/m2,d1-5)、亚叶酸钙(CF,130mg/m2,d1-5)加草酸铂(L-OHP,130mg/m2,d1)全身化疗,每21天为1个周期,共4到6个周期。A组时辰化疗时采用便携式微电脑输液泵定时给药:5-Fu和CF用药时间在22:00至次日10:00,其中75%的剂量在3:00至5:00滴入;L-OHP给药时间在10:00至22:00,其中75%剂量在3:00PM至5:00PM。B组用药时间安排在正常上班时间。结果:有效率(CR+PR)和临床获益率(CR+PR+NC)在A组分别为43.9%和82.9%,B组分别38.1%和78.5%,两组的有效率和临床获益率差别均无统计学意义(P>0.05);中位生存时间和无进展时间A组分别为18.5个月和7个月,B组分别为17.5个月和6个月;1年和2年生存率A组分别为75.6%和21.9%,B组分别为66.7%和21.4%;两组的总生存率无差别(P>...
Objective:To evaluate the therapeutic efficacy and toxicity of chronomodulated chemotherapy regimen with 5-Fluorouracil and oxaliplatin for late-stage colorectal carcinoma.Methods: 83 patients with late-stage colorectal carcinoma were randomly divided into two groups to receive either chronomodulated chemotherapy ( group A, 41 cases) or routine chemotherapy ( group B, 42 cases). All of these patients were treated with intravenous 5-Fluorouracil (700 mg/m2, d1-5),folinic acid (130 mg/m2, d1-5) and oxaliplati...
出处
《肿瘤预防与治疗》
2009年第1期26-29,117,共5页
Journal of Cancer Control And Treatment
关键词
大肠癌
5氟尿嘧啶
草酸铂
时辰化疗
Colorectal Carcinoma
5-Fluorouracil
Oxaliplatin
Chronomodulated Chemotherapy
