摘要
目的:研究酸枣仁总黄酮在大鼠尿液和粪便中的代谢与排泄。方法:将SD大鼠灌胃酸枣仁总黄酮提取物后,于不同时间收集尿液和粪便。经大孔吸附树脂处理尿液和粪便,采用高效液相色谱(HPLC)和高效液相色谱-质谱联用(LC-MSn)法检测尿液和粪便中的原型药和代谢产物。结果:在尿液和粪便中均检测到总黄酮中的主要化合物酸枣仁黄酮碳苷和6″′-阿魏酰酸枣仁黄酮碳苷,并发现一个主要代谢产物酸枣仁黄酮次级碳苷(M1)。结论:酸枣仁总黄酮在大鼠尿液和粪便中主要以原型药酸枣仁黄酮碳苷和6″′-阿魏酰酸枣仁黄酮碳苷的形式排出,少量以代谢产物的形式如酸枣仁黄酮次级碳苷排泄。
Objective:To study the metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces.Method:The urine and feces of rats were collected at different times after orally administration of total flavonoids from Semen Ziziphi Spinosae,disposed by HP-20 macroporous resin,and then detected by both HPLC and LC-MSn methods.Result:Two main proto-drugs,spinosin and 6″′-feruloylspinosin,along with a metabolite,swertish(M1),are detected in both urine and feces of rat.Conclusion: Flavonoid...
出处
《中国中药杂志》
CAS
CSCD
北大核心
2009年第3期340-343,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(20432030
20742005)
长江学者和创新团队计划项目(985-2-063-112)
