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用于基因传输及磁共振显像的聚乙烯亚胺-g-聚己内酯共聚物的合成与表征 被引量:6

SYNTHESIS AND CHARACTERIZATION OF POLYETHYLENIMINE-g-POLY(ε-CAPROLACTONE) COPOLYMER FOR GENE DELIVERY AND MAGNETIC RESONANCE IMAGING
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摘要 采用可生物降解的聚己内酯改性聚乙烯亚胺,得到两亲性的接枝共聚物(PEI-g-PCL).该共聚物通过溶剂挥发法在水中自组装形成纳米粒子,其内部负载有超顺磁性四氧化三铁纳米粒子(SPIO)及质粒DNA(pDNA).研究表明,PEI-g-PCL聚合物自组装形成的颗粒为胶束状,无论是否负载SPIO纳米粒子都可以有效地负载pDNA,并对293细胞具有较高的转染效率.此类载体有望在基因转染的过程中利用磁共振手段进行实时、无创观测. Gene therapy is a promising approach to treating diseases that caused by genetic defects or mutation.Non-invasive imaging of gene is a powerful tool in understanding the biodistribution and pharmacokinetics of vectors after in vivo administration.In the current research,amphiphilic copolymers,which were utilized to deliver a magnetic resonance imaging(MRI) contrast agent and pDNA simultaneously,were obtained by modifying hyperbranched polyethylenimine with biodegradable hydrophobic segment(PCL).Synthesis of...
出处 《高分子学报》 SCIE CAS CSCD 北大核心 2009年第2期104-110,共7页 Acta Polymerica Sinica
基金 国家自然科学基金(基金号50673103) 博士点基金(基金号20060558083) 广东省自然科学基金(基金号7003703)资助项目
关键词 聚乙烯亚胺 聚己内酯 胶束 基因传输 Polyethylenimine Poly(ε-caprolactone) Micelle Gene delivery
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参考文献1

  • 1Darin Y. Furgeson,Richard N. Cohen,Ram I. Mahato,Sung Wan Kim. Novel Water Insoluble Lipoparticulates for Gene Delivery[J] 2002,Pharmaceutical Research(4):382~390

同被引文献65

  • 1汪立刚,文原梅,周亮.三阴性乳腺癌用药进展[J].中国现代应用药学,2022,39(11):1509-1516. 被引量:8
  • 2张维,刘相丽,张猛,史清洪.末端功能化的树枝状聚合物载体与质粒组装的热力学和动力学[J].高分子学报,2013,23(8):1025-1032. 被引量:4
  • 3张蕾,张阳德,翟登高,潘一峰.聚丙交酯乙交酯纳米粒的制备及生物学效能的研究[J].中国现代医学杂志,2007,17(11):1326-1329. 被引量:6
  • 4Cho EC, Glaus C, Chen J, et al. Inorganic nanoparticle- based contrast agents for molecular imaging [J]. Trends Mol Med ,2010,16(12) :561 - 573.
  • 5Wang X,Wei F, Liu A, et al. Cancer stem cell labeling using poly (L-lysine)-modified iron oxide nanoparticles [J]. Biomaterials,2012,33(14) :3719 - 3732.
  • 6Wen M,Li B, Ouyang Y, et al. Preparation and quality test of superparamagnetic iron oxide labeled antisense oligodeoxynucleotide probe: a preliminary study [J]. Ann Biomed Eng ,2009,37(6):1240- 1250.
  • 7RichardsJM, Shaw CA, Lang NN, et al. In vivo mononuclear cell tracking using superparamagnetie particles of iron oxide: feasibility and safety in humans [J]. Circ Cardiovasc Imaging, 2012,5 (4) : 509 - 517.
  • 8Liu G, Swierczewska M, Lee S, et al. Functional nanopartieles for molecular imaging guided gene delivery [J]. Nano Today ,2010,5(6) :524 - 539.
  • 9Tong L,Zhao M,Zhu S,et al. Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging of cancer [J]. Front Med, 2011,5 (4) :379- 387.
  • 10Jiang J,Chen Y,Zhu Y,et al human prostate cancer cells Efficient in vitro labeling of with superparamagnetic iron oxide nanoparticles [J]. Cancer Biother Radiopharm, 2011,26(4) :461 - 467.

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