摘要
目的探讨慢性乙型肝炎患者肠源性内毒素与细胞免疫功能的关系,以寻找控制慢性乙型肝炎进展的有效途径。方法选取慢性乙型肝炎患者106例,健康对照组45例,检测血清内毒素、IL-2、TNF-α、CD4+、CD8+细胞因子水平,运用统计学方法分析。结果慢性乙型肝炎组ET、TNF-α水平明显升高,IL-2水平明显降低,CD4+亚群明显降低,CD8+亚群明显升高,CD4+/CD8+比值明显降低(P<0.01)。结论慢性乙型肝炎患者血清内毒素水平明显升高,同时细胞免疫功能低下且紊乱。
Objective To study the relationship between cellular immune function and intestinal endotoxin(IET) in chronic hepatitis B(CHB) patients and search an efficient therapy for controlling the development of CHB.Methods One hundred and six CHB cases and 45 controls were chosen to detect the levels of serum endotoxin,IL-2,TNF-α,CD4+ and CD8+,statistical method was used to analyze the results.Results In CHB patients,levels of ET,TNF-α and the percentages of CD4+ increased significantly,while levels of IL-2,the percentages of CD4+ and ratios of CD4+/CD8+ decreased markedly compared with normal control(P<0.01).Conclusions In CHB patients,levels of ET increased significantly,while the cellular immune function decreased and disordered markedly compared with normal controls.
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2008年第2期48-51,共4页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
关键词
慢性乙型肝炎
肠源性内毒素
细胞免疫功能
Chronic hepatitis B
Intestinal endotoxin
Cellular immune function
