摘要
目的探讨2型糖尿病患者血浆肿瘤坏死因子-α(TNF-α)水平的变化。方法选取正常对照(正常组)和2型糖尿病(DM2组)为研究对象,再将2型糖尿病组按体质量指数(BMI)<25的分为DM2a组,≥25的分为DM2b组;用放射免疫法测定各组的TNF-α水平并比较。结果正常对照组血浆TNF-α为(1.09±0.52)ng/ml,DM2a组为(2.01±0.61)ng/ml,比正常组升高(P<0.05);DM2b组为(2.49±0.77)ng/ml,与正常组比显著升高(P<0.01),与DM2a组比,两者差异亦有显著性(P<0.01)。结论2型糖尿病患者血浆TNF-α水平显著高于正常人,并与肥胖有一定的关系。
Objective To study the level change of plasma tumor necrosis factor-α(TNF-α)in type 2 diabetes.Methods The plasma concentrations of TNF-α were determined by immunoradiometric in 17 control subjects (Control group),and 24 type 2-diabetes (DM2 group),which were further subdivided into 2 subgroups based on BMI as DM2a group (BMI<25) and DM2b group(BMI≥25).Results The plasma TNF-α level was(1.09±0.52) ng/ml in Control group;the TNF-αlevel in DM2a and DM2b all increased significantly as compared with Control group (P<0.05,P<0.01),and the TNF-α level in DM2b was significantly higher than that in DM2a(P<0.01). Conclusion The concentration of TNF-α increased significantly in type 2-diabetes as compared to normal subjects,and it was correlative with obesity.
出处
《中国老年保健医学》
2007年第6期21-22,共2页
Chinese Journal of Geriatric Care
关键词
糖尿病
肿瘤坏死因子-Α
胰岛素抵抗
diabetes mellitus tumor necrosis factor-α insulin resistance
