摘要
目的研究血清尿酸水平与冠脉病变严重程度的关系。方法选择我院心血管中心2005年5月至2006年8月经过冠脉造影证实确诊为冠心病的患者共283例。根据冠脉病变程度将患者分成狭窄组(主干或分支直径狭窄程度>50%)和对照组(主干或分支直径狭窄程度≤50%)。再将狭窄组按狭窄累及范围分为单支组,双支组和多支(3支以上)组。采用尿酸酶—过氧化物酶法测定患者的血尿酸,并将狭窄组和对照组患者的血尿酸值加以比较,同时,在狭窄组中,将不同亚组患者的血尿酸浓度进一步加以比较,明确血尿酸浓度与冠脉病变程度的关系。结果狭窄组患者的血尿酸浓度明显高于对照组(P<0.01),差异有统计学意义。在狭窄组中,单支组与双支组血尿酸浓度无显著性差异,多支组血尿酸浓度显著高于单支组和双支组,差异有统计学意义(P<0.05)。结论血尿酸水平与冠状动脉狭窄程度及范围呈正相关,血尿酸可作为衡量冠心病冠脉病变发展程度和预测冠心病预后的观察指标。
Objective To study the relationship between the serum uric acid (SUA) level and severity of coronary artery disease. Methods 283 in-patients with coronary heart disease confirmed by coronary angiography, 198 males and 85 females, were divided into control group (n=65, with the extent of stenosis of coronary artery ≤50%), and stenosis group (n=218, with the extent of stenosis of coronary artery >50%) which were further subdivided into single branch (SB) subgroup (n=79), two-branch (TB) subgroup (n=62), and multiple branch (MB) subgroup (n=77) according to the number of branches involved. Peripheral blood samples were collected from these patients. Uricase method was used to measure the SUA.Results The SUA of the stenosis group was 353.6±67.5 μmol/L. significantly higher than that of the control group (303.1±66.7μmol/L, P<0l.01). The SUA level of the MB subgroup was 370.0±74.6 μmol/L, significantly higher then those of the TB and SB subgroups (362.4±60.1 μmol/L and 330.8±59.7 μmol/L respectively, both P<0.05), however, the SUA level of the TB subgroup was not significantly different from that of the SB subgroup. Conclusion Positively correlated with the degree and range of stenosis of coronary heart diseases, SUA may be used as an observational index for severity of coronary heart disease.
出处
《中国急救复苏与灾害医学杂志》
2007年第3期139-141,共3页
China Journal of Emergency Resuscitation and Disaster Medicine
关键词
血尿酸
冠心病
冠脉病变程度
Serum uric acid
Coronary heart disease
Degree
