摘要
目的观察院外急救中应用抗凝治疗老年不稳定型心绞痛的疗效。方法2002年11月至2005年2月,73例院外接诊的老年不稳定性心绞痛患者,随机分为治疗组(n=36)和对照组(n=37),对照组采用常规治疗,治疗组加用抗凝治疗,比较二组患者治疗后的疗效。结果治疗组患者无1例死亡,总有效率(94.4%),明显高于传统治疗对照组(67.6%),差异有统计学意义(P<0.05)。治疗前两组患者血流动力学指标全血黏度/纤维蛋白原/血小板聚集指数差异无统计学意义;治疗后抗凝治疗组各指标明显改善,与治疗前差异有统计学意义(P<0.01或P<0.05);而传统治疗组患者治疗前后血流动力学指标差异无统计学意义。结论院外急救中应用抗凝治疗老年不稳定型心绞痛可明显改善心肌缺血,预防血栓形成,能为入院后的进一步治疗赢得时间。
Objective To explore the therapeutic effects of anticoagulant administration in pre-hospital emergency medical care on unstable angina pectoris (UA) in elder patients. Methods Seventy-three elder patients with UA,49 males and 24 females,aged 67±(64～82),were randomly divided into 2 groups: treatment group,injected hypodermically with low molecular weight heparin 5 000 U and administered orally with aspirin enteric-coated tablet 75 mg in addition to routine treatment during pre-hospital emergency medical care,and control groups,receiving only the routine treatment. ECG,platelet count,and hemodynamic parameters were measured before and after treatment. Results The general effective of the treatment group was 94.4%,significantly higher than that of the control group (67.6%).There were not significant differences in whole blood viscosity,fibrinogen,and aggregation index before treatment between these 2 groups.The values of these parameters were all significantly lowered after treatment (P<0.01 or P<0.05),however,these values did not changed remarkably after the treatment in the control group. Conclusion Anticoagulant administration during prehospital medical care in elder UA patients helps ameliorate myocardial ischemia and prevent thrombosis,thus winning time for further treatment.
出处
《中国急救复苏与灾害医学杂志》
2007年第10期586-588,共3页
China Journal of Emergency Resuscitation and Disaster Medicine
关键词
抗凝治疗
老年不稳定性心绞痛
院外急救
Anticoagulant treatment
Unstable angina pectoris in elders
First-aid
