期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

正确理解小剂量阿司匹林导致脑出血的危险性 被引量：7

How to Understand Risk of Hemorrhagic Stroke with the Use of Low-dose Aspirin
下载PDF
导出
摘要 　　阿司匹林在心脑血管疾病的一级和二级预防中均显示出卓越的作用.对任何缺血性血管疾病患者,阿司匹林可以使严重心血管事件风险下降约1/4,使非致死性心肌梗死风险下降约1/3,使非致死性卒中风险下降约1/4,使血管性死亡风险下降约1/6,且在长期使用时,小剂量阿司匹林(75～150 mg/d)与较大剂量(160～325 mg/d,或500～1500 mg/d)具有相同或更好的疗效[1].尽管阿司匹林是效益风险比很高的药物,但是,目前在我国阿司匹林的使用率极低,冠心病患者中仅为14.38%,卒中患者中还不到14%,且对阿司匹林的使用极不规范,超过50%的患者使用50 mg/d以下的无效剂量[1,2].导致这种情况发生有多种原因,除对阿司匹林存在模糊认识和缺乏指导等原因以外,一个重要原因是目前许多医生并不了解小剂量阿司匹林的出血发生率,并过分担心阿司匹林的脑出血副作用.……
作者 贺茂林
机构地区 北京世纪坛医院神经内科
出处 《中国卒中杂志》 2007年第2期95-97,共3页 Chinese Journal of Stroke
关键词 阿司匹林 脑出血 卒中 心血管疾病 预防
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献13

  • 1[1]Antithrombotic Trialists' Collaboration.Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death,myocardial infarction,and stroke in high-risk patients[J].BM J,2002,324:71-86.
  • 2吴敌,王伊龙,马锐华,包华,王春雪,王拥军.缺血性脑卒中患者二级预防中抗血栓药物使用现况调查[J].中华老年心脑血管病杂志,2006,8(5):325-328. 被引量：11
  • 3[3]International Stroke Trials Collaborative Group.IST:a randomised trial of aspirin,subcutaneous heparin,both,or neither among 19 435 patients with acute ischaemic stroke[J].Lancet,1997,349:1569-1581.
  • 4[4]CAST Collaborative Group.CAST:randomised placebo-controlled trial of early aspirin use in 20 000patients with acute ischaemic stroke[J].Lancet,1997,349:1641-1649.
  • 5[5]Serebruany VL,Steinhubl SR,Berger PB,et al.Analysis of risk of bleeding complications after different doses of aspirin in 192 036 patients enrolled in 31 randomized controlled trials[J].Am J Cardiol,2005,95:1218-1222.
  • 6[6]Serebruany VL,Malinin AI,Eisert RM,et al.Risk of bleeding complications with antiplatelet agents:metaanalysis of 338 191 patients enrolled in 50 randomized controlled trials[J].Am J Hematol,2004,75:40-47.
  • 7[7]Weisman SM,Graham DY.Evaluation of the benefits and risks of low-dose aspirin in the secondary prevention of cardiovascular and cerebrovascular events[J].Arch Intern Med,2002,162:2197-2202.
  • 8[8]McQuaid KR,Laine L.Systematic review and metaanalysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials[J].Am J Med,2006,119,624-638.
  • 9[9]Gorelick PB,Weisman SM.Risk of hemorrhagic stroke with aspirin use:an update[J].Stroke,2005,36:t801-1807.
  • 10[10]Ridker PM,Cook NR,Lee IM,et al.A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women[J].N Engl J Med,2005,352:1293-1304.

二级参考文献18

  • 1Antithrombotic Trialists′ Collaboration.Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death,myocardial infarction,and stroke in high risk patients.BMJ,2002,324:71-86.
  • 2Swedish Aspirin Low-Dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events.The SALT Collaborative Group.Lancet,1991,338:1345-1349.
  • 3European Stroke Prevention Study 2.Efficacy and safety data.J Neurol Sci,1997,151 Suppl:S1-S77.
  • 4Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke.EAFT (European Atrial Fibrillation Trial) Study Group.Lancet,1993,342:1255-1262.
  • 5Ridker PM,Cook NR,Lee IM,et al.A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women.N Engl J Med,2005,352:1293-1304.
  • 6The International Stroke Trial (IST):a randomised trial of aspirin,subcutaneous heparin,both,or neither among 19435 patients with acute ischaemic stroke.International Stroke Trial Collaborative Group.Lancet,1997,349:1569-1581.
  • 7CAST:randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke.CAST (Chinese Acute Stroke Trial) Collaborative Group.Lancet,1997,349:1641-1649.
  • 8Antiplatelet Trialists' Collaboration. Collaborative meta-analysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients[J]. BMJ, 2002,324: 71-86.
  • 9Fuster V, Ryden LE, Asinger RW, et al. ACC/AHA/ESC guidelines for the management of patienta with atrial fibrillation: Executive summary.A report of the American Collage of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences: Developed in collaboration with North American Society of Pacingand Electr-physiology[J]. J Am Coll Cardiol, 2001,38: 1231-1266.
  • 10Albers GW, Easton JD, Sacco RL, et al. Antithrombotic and thrombolytic therapy for ischemic stroke[J]. Chest, 1998,114: 683-98S.

共引文献84

同被引文献46

引证文献7

二级引证文献19

中国卒中杂志
2007年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部