摘要
目的评价口服塞克硝唑片治疗滴虫阴道炎的有效性和安全性。方法采用随机双盲、平行对照设计,入选滴虫阴道炎患者96例,塞克硝唑片组与替硝唑片组各48例,对其临床疗效和滴虫清除率进行比较,并观察用药后不良事件和实验室检查异常的发生情况。结果用药后塞克硝唑片组痊愈率和有效率分别为82.6%和93.5%;替硝唑片组痊愈率和有效率分别为72.3%和95.7%,两组之间比较差异无统计学意义(P>0.05)。塞克硝唑片组滴虫清除率为93.8%;替硝唑片组滴虫清除率为95.8%,两组之间比较差异无统计学意义(P>0.05)。96例病例中无不良事件与严重不良事件发生;塞克硝唑片组实验室检查异常发生率为0.00%,替硝唑片组实验室检查异常发生率为2.08%,两组之间比较差异无统计学意义(P>0.05)。结论口服塞克硝唑片治疗滴虫阴道炎安全、有效。
Objective To evaluate the efficacy and safety of secnidazole tablet in the treatment of trichomonal vaginitis.Methods A randomized, double-blinding, parallel-controlled clinical trial including 96 cases suffered trichomonal vaginitis was conducted. Forty-eight cases in trial group were given secnidazole tablets and 48 cases in control group were given tinidazole tablets.Conclusion clinical efficacy and the eradicated rates of trichomonad between trial group and control group. The adverse events and abnormal results of laboratory test were observed.Results After treatment, the cure rates were 82.6% in trial group and 72.3% in control group, the efficacy rates were 93.5% in trial group and 95.7% in control group. There were no significant differences between two groups (P>0. 05). The eradicated rates of trichomonad were 93.8% in trial group and 95.8% in control group. There were no significant differences between two groups in eradicated rates of trichomonad (P>0. 05). There were no adverse events and severe adverse events happened in all these 96 cases. The rates of abnormal results of laboratory test were 0.00% in trial group and 2.08% in control group. There were no significant differences between two groups in safety(P>0.05). Conclusion Secnidazole tablet is effect and safe in the treatment of trichomonal vaginitis.
出处
《中国实用医药》
2007年第7期1-5,共5页
China Practical Medicine
关键词
塞克硝唑
替硝唑
滴虫阴道炎
Secnidazole
Tinidazole
Trichomonal vaginitis
