期刊文献+

血脂相关指标与动脉粥样硬化发展阶段的相关性研究 被引量:3

The correlations between the blood lipids and the stages of atherosclerosis
下载PDF
导出
摘要 目的通过检测动脉粥样硬化(As)不同发展阶段的各种血脂相关指标,来探讨各种检测值与As各个发展阶段的相关性。方法随机选择健康体检者60例(As(-)组)、脑As无并发症患者24例(As(+)组)、As性脑栓塞患者67例(As(++)组),酶化学法测定血清三酰甘油(TG)、总胆固醇(TC),直接法测定低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDLC),免疫透射比浊法测定载脂蛋白AI(ApoAI)、载脂蛋白B100(ApoB100)、脂蛋白(a)(LP(a)),并对3组的检测值进行统计分析。结果As(+)组与As(-)组比较,TG、TC、LDLC、ApoB100、LP(a)、ApoB100/ApoAI增高(P<0.05),HDLC、ApoAI降低(P<0.05)。As(++)组与As(+)组比较,ApoB100、LP(a)、ApoB100/ApoAI增高(P<0.05)。As(++)组与As(-)组比较,ApoB100、LP(a)、ApoB100/ApoAI显著增高(P<0.01)。结论TG、TC、LDLC、HDLC、ApoAI、ApoB100、LP(a)、ApoB100/ApoAI水平与As的早期发展阶段相关,而且ApoB100、LP(a)、ApoB100/ApoAI水平与As的晚期发展阶段相关。 Objective The correlations between the blood lipids and the stages of atherosclerosis (As) were studied via epidemiological investigations. Methods 60 healthy adults (Group As(-)), 24 atherosclerotic patients with no complication (Group As(+)), 67 atherosclerotic patients with cerebral infarction (Group As(++)) were selected randomly, and some of their serum data were measured including triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDLC), apolipoprotein AI (ApoAI), apolipoprotein B100 (ApoB100), lipoprotein (a) (LP(a)) and ApoB100/ApoAI ratio. Results As Group As(+) compared with Group As(-), TG, TC, LDLC, ApoB100, LP(a), ApoB100/ApoAI increased (P<0.05), and HDLC, ApoAI decreased (P<0.05). As Group As(++) compared with Group As(+), ApoB100, LP(a) and ApoB100/ApoAI increased (P<0.05). As Group As(++) compared with Group As(-), ApoB100, LP(a) and ApoB100/ApoAI increased significantly (P<0.01). Conclusion TG, TC, LDLC, HDLC, ApoAI, ApoB100, LP(a) and ApoB100/ApoAI correlated with the early stage of As, what was more, ApoB100, LP(a) and ApoB100/ApoAI correlated with the late stage of As.
出处 《中国实用医药》 2007年第15期24-26,共3页 China Practical Medicine
基金 华南在大学资助 (项目编号:05Z14 06Z12)
关键词 动脉粥样硬化 血脂 相关性 Atherosclerosis Blood lipids Correlation
  • 相关文献

参考文献1

二级参考文献11

  • 1Ikewaki K,Matsunaga A,Han H,et al.A novel two nucleotide deletion in the apolipoprotein AⅠ gene,ApoAⅠ Shinbashi,associated with high density lipoprotein deficiency,corneal opacities,planar xanthomas,and premature coronary artery disease.Atherosclerosis,2004,172∶39-45.
  • 2Angotti E,Mele E,Costanzo F,et al.A polymophism(G-A transition) in the -78 position of the apolipoprotein AⅠ promoter increase transcription efficiency.J Biol Chem,1994,269∶17371-17374.
  • 3Smith JD,Brinton EA,Breslow JL.Polymorphism in the human apolipoprotein AⅠ gene promoter region:association of the minor allele with decreased production rate in vivo and promoter activity in vitro.J Clin Invest,1992,89∶1796-1800.
  • 4Braschi S,Neville TA,Vohl MC,et al.Apolipoprotein AⅠ charge and conformation regulate the clearance of reconstituted high density lipoprotein in vivo.J Lipid Res,1999,40∶522-532.
  • 5Wang XL,Badenhop R,Humphrey KE,et al.New MspⅠ polymorphism at +83 bp of the human apolipoprotein AⅠ gene:association with increased circulationary high density lipoprotein,cholesterol levels.Genet Epidemiol,1996,13∶1-10.
  • 6Zhang B,Bai H,Liu R,et al.Serum high-density lipoprotein-cholesterol levels modify the association between plasma levels of oxidatively modified low-density lipoprotein and coronary artery disease in men.Metabolism,2004,53∶423-429.
  • 7Duverger N,Kruth H,Emmanuel F,et al.Inhibition of atherosclerosis development in cholesterol-fed human apolipoprotein AⅠ-transgenic rabbits.Circulation,1996,94∶713-717.
  • 8Sorci-Thomas MG,Thomas MJ.The effects of altered apolipoprotein AⅠ structure on plasma HDL concentration.Trends Cardiovasc Med,2002,12∶121-128.
  • 9Suit E.Luciferase Assay Guide Book:protocols and information for measuring firefly luciferase expressed in cells.San Diego Calif U S A,1992.8-10.
  • 10Karathanasis KS.Apolipoprotein multigene family:tandem organization of human apolipoprotein AⅠ,CⅢ and AⅣ gene.Proc Natl Acad Sci U S A,1985,82∶6374-6378.

共引文献3

同被引文献41

引证文献3

二级引证文献57

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部