摘要
目的研究分析部分重要凝血和抗凝因子与脑梗死发生的关系。方法采用凝固法测定急性脑梗死组、非脑血管疾病对照组和正常健康对照组血浆中纤维蛋白原含量、凝血因子Ⅶ和Ⅷ活性、蛋白 C 活性,以及凝血酶原时间和活化部分凝血活酶时间等指标,并在三组间进行比较。结果急性脑梗死组纤维蛋白原含量和凝血因子Ⅶ活性显著高于非脑血管组和正常对照组.脑梗死组凝血因子Ⅷ活性高于其他两组,但与正常组比较差异不显著;脑梗死组的蛋白 C 活性显著低于其他两组;上述所有指标在非脑血管疾病组和正常对照组之间无显著差异;凝血酶原时间和活化部分凝血活酶时间在三组间无显著差异。结论纤维蛋白原浓度升高、凝血因子Ⅶ和Ⅷ活性升高以及蛋白 C 活性下降与脑梗死的发生存在一定关联性,提示纤维蛋白原等因素可能是脑梗死发生和发展中的重要危险因素。
Objective To study the relationship between several hemostatic factors and the risk of ischemic stroke.Methods We measured and studied fibrinogen concentration,factor Ⅶ activity,factor Ⅷ activity,protein C activity,prothrombin time and activated partial thromboplastin time in 50 patients with ischemic stroke,50 patients with non-cerebrovascular disease and 50 healthy controls by clotting assays.Results The fibrinogen concentration and factor Ⅶ activity in ischemic stroke group were significantly higher than those in the non-cerebrovascular disease group and healthy controls;The protein C activity in the ischemic stroke group was significantly lower than that in other two groups.Although the factor Ⅷ activity in the ischemic stroke group was also higher than that in other two groups,there was no statistical difference between the ischemic stroke group and the healthy control group.As for all parameters which we measured there was no significant difference between the non-cerebrovascular disease group and healthy controls.As for prothrombin time and activated partial thromboplastin time there was no significant difference among the three groups.Conclusion There is a relationship between ischemic stroke and fibrinogen,factor Ⅶ, factor Ⅷ and protein C.It implies that fibrinogen and others may be the important factors and play a role in pathogen- esis of ischemic stroke.
出处
《神经病学与神经康复学杂志》
2006年第4期193-195,共3页
Journal of Neurology and Neurorehabilitation
