摘要
目的:探讨无症状性脑梗死(SCI)患者血清脂蛋白(α)[Lp(α)]水平与纤溶活性的关系。方法:采用Olimpus-AU5400全自动生化分析仪测定53例SCI患者和55例健康者(对照组)血清Lp(α)水平,用发色底物法检测血浆组织型纤溶酶原激活物(t-PA)和纤溶酶原激活物抑制剂(PAI)活性,并对SCI患者的血清Lp(α)水平与血浆t-PA和PAI活性进行相关分析。结果:SCI组血清Lp(α)水平[(238.48±48.76)mg/L]高于对照组[(198.36±38.42)mg/L,t=4.759,P<0.05];SCI组t-PA活性[(0.11±0.01)IU/mL]低于对照组[(0.49±0.12)IU/mL,t=-22.973,P<0.05],而PAI活性[(0.86±0.22)AU/mL]高于对照组[(0.48±0.10)AU/mL,t=11.626,P<0.05]。SCI组血清Lp(α)水平与t-PA活性呈负相关(r=-0.676,P<0.05),与PAI活性呈正相关(r=0.813,P<0.05)。结论:血清Lp(α)水平升高是SCI重要的危险因素;其可能通过降低t-PA的活性和(或)增强PAI的活性,干扰纤溶系统的平衡,参与SCI的形成。
Aim:To investigate the relationship between serum lipoprotein (α) [Lp (α)] and fibrinolytic activity in patients with silent cerebral infarction (SCI).Methods:The serum Lp(α) levels were measured by Olimpus-AU 5400 automatic biochemistry analyzer in 53 patients with SCI and 55 healthy controls. The plasma tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) activities were determined by chrimogenic substrate method. The correlation analysis was also made between serum Lp (α) an...
出处
《郑州大学学报（医学版）》
CAS
北大核心
2009年第5期966-968,共3页
Journal of Zhengzhou University(Medical Sciences)
基金
河南省医学科技攻关计划项目(2006)
郑州市科技攻关计划项目064SGYS33216-2
