摘要
目的探讨杀伤细胞免疫球蛋白样受体(KIR)基因型在桥本甲状腺炎患者中的分布规律。方法采用序列特异性引物聚合酶链反应(PCR-SSP)的方法,分析100例桥本甲状腺炎(HT)患者和260例正常对照人群(正常对照组)的KIR基因型。结果桥本甲状腺炎患者中2种基因型3DL3,2DS2,2DL3,2DP1,2DL1,2DL4,3DL1,2DS4,3DL2和3DL3,2DL3,2DP1,2DL1,2DL4,3DL1,3DS1,2DS1,2DS4,3DL2频率高于正常对照组(P<0.05,P<0.01),1种基因型3DL3,2DL3,2DP1,2DL1,2DL4,3DL1,3DS1,2DL5,2DS5,2DS1,2DS4,3DL2低于正常对照组(P<0.05);HT患者组携带6个以上抑制性KIR基因的基因型总频率明显少于对照组(39%vs 56.2%,P<0.01)。结论KIR基因型在桥本甲状腺炎患者与正常人群分布的差异可能与桥本甲状腺炎的发病有关。
Objective Killer cell immunoglobulin-like receptor(KIR) can modulate activity of NK and T lymphocytes.To investigate if the KIR genotype possesses a susceptibility to Hashimoto′s thyroiditis(HT).Methods The KIR genotypes in 100 HT patients and 260 randomly selected healthy controls(the control group) were determined using PCR-SSP.Results The two genotype frequencies of 3DL3,2DS2,2DL3,2DP1,2DL1,2DL4,3DL1,2DS4,3DL2 and 3DL3,2DL3,2DP1,2DL1,2DL4,3DL1,3DS1,2DS1,2DS4,3DL2 were significantly higher in the patient ...
出处
《山东大学学报（医学版）》
CAS
北大核心
2009年第8期1-4,共4页
Journal of Shandong University:Health Sciences
基金
国家自然科学基金项目资助课题(30470815,30371304)
