摘要
目的探讨晚期大肠癌有效治疗方法,改善该类患者生存质量、延长生存时间。方法静脉化疗,应用羟基喜树碱(HCPT)/甲酰四氢叶酸钙(CF)+5-氟脲嘧啶(5-FU)方案:HCPT 12mg/m2静脉滴注D1到D5。CF 200mg/m2+5-FU 300mg/m2静脉滴注D1到D5,每3-4周1次,3周期为1疗程。腹腔化疗:用5-氟脲嘧啶(5-FU)+顺铂(DDP),5-FU 750mg/m2+DDP 60mg/m2自Tenckhoff管或Port-A-Cath泵系统注入腹腔,腹水者腹腔穿刺注入,每10-15天1次,2-4次为1疗程。各完成1疗程后评价。结果近期疗效,32例中,CR 3例,PR 10例,SD 9例,PD 9例,总有效率40.6%。随诊2年, 中位生存期11.8月,1年生存率56.2%,2年生存率21.9%。毒副反应主要为骨髓抑制,腹泻,腹膜炎。结论含羟基喜树碱联合方案静脉化疗联合腹腔化疗是治疗晚期大肠癌安全,有效的方法。
Objective To explore the effective method in the treatment of advanced colorectal cancer. Methods 32 patients with advanced colorectal cancer were treated with intravenous(Ⅳ) and intraperitional chemotherapy (IP) , HCPT12mg/m2 IV infusion D1 to D5 ,Leucovorin(CF)200mg -2h Ⅳ infusion followed by 5 - fluorurcil(5 - fu)300mg/m2 -4h Dl to D5. The courses repeat every 3 -4 weeks for 3 cycle. IPC:5 - fu 750mg/m2 in 1000 - 1500ml 5% glucose was administered by IP,the courses repeat every 10 -15 days for 2 -4 cycle. Tumor assessment was dane after each course. Results In 32 cases evaluable for efficacy ,3CR,10PR,9SD, 9PD. The overall response rate was 40. 6%. Follow - up 2 years,median survival date 11.8 months,the 5 - year survival rate was 56. 2% ,2 - year survival rate was 21.9% . The mayor side effects were myelosuppression,diarrhea,peritonitis. All was and mild and toter-able. Conclusion Intravenous chemotherapy with HCPT - containing regimen plus IPC are effective, safe in the treatrrient of advance colorectal cancer.
出处
《中国医药导报》
CAS
2005年第15期37-38,共2页
China Medical Herald
关键词
大肠癌
静脉化疗
腹腔化疗
联合
Advance colorectal cancer
Intravenous chemotherapy
Intraperitional chemotherapy
