摘要
目的观察腰椎间盘突出症患者椎管外软组织炎症反应。方法对10例腰椎间盘突出症手术患者的腰椎新鲜棘肌样本进行磷脂酶A_2(PLA_2)活性测定，与10例非炎性疾患的手术患者附着于肋骨的胸大肌标本对照。结果实验组样本测定数值显著高于对照组。电镜检查显示肌细胞核周线粒体肿胀、数目少，间质内见幼稚血管网及单核吞噬细胞。结论腰椎间盘突出症患者椎管外软组织存在损伤性炎症，是引起腰腿痛的重要因素。
Objective To observe the aseptic inflammation of soft trissue in the extra vertebral canal of patients wish lumbar disc herniation.Methods We dertermined the PLA_2 activity of 10 patients'fresh spinal muscle specimen as test group and 10 patients'pectoralis major muscle attached rib specimen as control group. The former with prolapse of lumbar intervertebral disc were treated by operation and the latte without inflammation disease were operated by other disease.Results The result was that the PLA_2 activity in test group was much higher than that in control group.We also examined the muscle of the test group by electron microscope,it showed that the decrease of quantity of mitochondria around myocyte nucleus, mitochondria swelling, juvenile vascular net in intercelular substance,and mononuclear－macrophage in vascular.Conclusion There was lesion inflammation of soft tissue in the extra vertebral canal of patient with lumbar disc herniation,it is one of the important pathogenies of low back and leg pain.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
2001年第12期43-44,共2页
Journal of Clinical Rehabilitative Tissue Engineering Research
关键词
腰椎间盘突出症
磷脂酶A2
软组织损害
炎症
prolapse of lumbar intervertebral disc
phospholipase A_2
soft tissue
inflammation
