摘要
Objective: To observe the therapeutic effect of Leyin (乐银,LY) in treating psoriasis maculata (PM) and its effects on cellular immunity and vagin al epithelial cell mitosis in experimental mice.Methods: In this clinical study, 260 out-patients of PM were randomly divided into the observed group ( n =160) and the control group ( n =100), who were treated with oral intake of LY and Yinxieling granule (YXL, 银屑灵冲剂) respectively to observe the therapeutic effect and the adverse reac tion. And a follow-up study was also conducted on them. In the experimental s tudy, delayed allergic model mice were treated with immunosuppressor(cyclophosph amide) and LY separately to observe the effects on their immune function and inh ibition of vaginal epithelial cell proliferation. Results: In the observed group, 8 patients (5%) were cured, 32 (20%) basically cured, 48 (30%) markedly improved, 48 (30%) improved and 24 (15%) unchanged, the total effective rate being 85%, while in the control group, the corresponding numbers were 4, 8 , 14, 38, 36 and 64% respectively, with the comparison of the total effective ra te between the two groups showing significant difference( P <0.01). Adverse r eactions were not found in the study. Experimental study showed that LY could e nhance the immune function of mice and had a certain inhibitory effect on vagina l epithelial cell proliferation. Conclusion: LY could treat PM effectively and shows immune enhan cing and anti-mitosis effect in mice.
Objective: To observe the therapeutic effect of Leyin (乐银,LY) in treating psoriasis maculata (PM) and its effects on cellular immunity and vagin al epithelial cell mitosis in experimental mice.Methods: In this clinical study, 260 out-patients of PM were randomly divided into the observed group ( n =160) and the control group ( n =100), who were treated with oral intake of LY and Yinxieling granule (YXL, 银屑灵冲剂) respectively to observe the therapeutic effect and the adverse reac tion. And a follow-up study was also conducted on them. In the experimental s tudy, delayed allergic model mice were treated with immunosuppressor(cyclophosph amide) and LY separately to observe the effects on their immune function and inh ibition of vaginal epithelial cell proliferation. Results: In the observed group, 8 patients (5%) were cured, 32 (20%) basically cured, 48 (30%) markedly improved, 48 (30%) improved and 24 (15%) unchanged, the total effective rate being 85%, while in the control group, the corresponding numbers were 4, 8 , 14, 38, 36 and 64% respectively, with the comparison of the total effective ra te between the two groups showing significant difference( P <0.01). Adverse r eactions were not found in the study. Experimental study showed that LY could e nhance the immune function of mice and had a certain inhibitory effect on vagina l epithelial cell proliferation. Conclusion: LY could treat PM effectively and shows immune enhan cing and anti-mitosis effect in mice.
基金
ThisarticleissupportedbythefundofIntegratedChineseTraditionalandWesternMedicinefromHealthBureauofTianjinCity(No.980 12 )
