摘要
目的 分析异位妊娠保守治疗的方法与效果。方法将340例异位妊娠按治疗方案分为5组,其中I组为期待治疗,Ⅱ组为中药治疗,Ⅲ组为甲氨蝶呤(MTX)50mg肌肉注射单次治疗,Ⅳ组为MTX 50mg多次肌肉注射治疗,V组为MTX 20 mg肌内注射,1次/日,连用5 d。结果MTX50mg单次治疗与MTX 20 mg连用5 d治疗效果相似。治疗前血β-HCG<500mIU/ml时,期待治疗与药物治疗成功率差异无显著性,而β—HCG>500 mIU时,治疗效果明显降低,β—HCG>1 000 mIU时,中药治疗效果明显不如MTXC,β-HCG>3 000 mIU/ml,MTX 50mg单次治疗成功率明显下降。β—HCG>5 000mIU/ml,MTX50mg im多次治疗成功率也明显下降,但仍高于单次治疗。结论 血β—HCG是指导和监测EP治疗的重要指标。治疗前β—HCG<3 000 mIU/ml时,MTX50 mg im单次治疗是有效而安全的;>3 000 mIU/ml,推荐MIX多次用药。
Objective To evaluate the methods and effects of conservative treatments in cases of ectopic pregnancy (EP) .Methods 340 cases of women with ectopic pregnancy were divided into five groups: group I : treated with expectancy; group II : treated with traditional Chinese medicine; group III : treated with single - dose of methotrexate (MTX) 50mg im; group IV: treated with multiple - dose of MTX 50 mg im; group V: treated with MTX 25 mg im Qdx5 .Results There were no differences the successful rate of treatment between group 3 and group 5, nor between group 1 and the others when serum β - HCG < 500 mIU/ml before treatments. The effect of traditional Chinese medicine was worse than MTX when β- HCG > 1 000 mIU/ml. Before treatment when β- HCG > 3 000 mIU/ml, or β- HCG> 5 000 mIU/ml, the successful rates decreased in group III and group IV respectively. Conclusions The serum B - HCG is an important parameter in guiding and monitoring treatments of EP. MTX 50mg im is efficient and safe when serum β - HCG < 3 000 mIU/ml, however, when β- HCG > 3 000 mIU/mL multiple -dose of MTX 50mg im is suggested.
出处
《中国妇产科临床杂志》
2001年第6期339-341,365,共4页
Chinese Journal of Clinical Obstetrics and Gynecology
关键词
异位妊娠
保守治疗
Ectopic pregnancy
Conservative treatment
