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肿瘤多药耐药逆转剂研究新进展 被引量：3

The new process of multidrug resistance reversal agents
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摘要 肿瘤耐药逆转剂的研究是抗肿瘤药物研究的重要策略。目前处于临床试验阶段的新逆转剂有Tariquidar(XR9576)、Zosuquidar(LY335979)、Laniquidar(R101933)、ONT-093、Elacridar(GF1210918)等,它们通过直接与P-gP结合,使P-gP丧失外排药物功能,从而抑制抗癌药物自胞内泵出细胞外,增加细胞内抗癌药物的积聚,逆转多药耐药性。新近发现一种治疗高血压和冠心病的β-肾上腺素受体阻断剂卡维地洛可以逆转肿瘤细胞对抗肿瘤药物的多药耐药,其逆转活性可与维拉帕米相当。
作者 徐峰 蔡卓夫
机构地区 第一军医大学珠江医院 广东医学院附属湛江中心人民医院
出处 《中国药物应用与监测》 CAS 2004年第3期57-59,共3页 Chinese Journal of Drug Application and Monitoring
基金 广东省医学科研基金资助项目(A2003471)
关键词 肿瘤 多药耐药性 药物研究
分类号 R979.1 [医药卫生—药品]
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参考文献22

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二级参考文献20

共引文献3

同被引文献11

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中国药物应用与监测
2004年 第3期

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