摘要
目的:分析讨论复方丹参注射液不良反应的主要类型和防范措施。方法:检索1994年～2004年清华同方生物医学数据库内的有关文献。结果:复方丹参注射液的不良反应132篇,其中短篇报道116篇,回顾性分析16篇,病例共计146例,男性大于女性,50岁以上发生率占68.96%(80例)。其发生不良反应的时间主要集中于2h内(占62.29%)。变态反应112例(占76.71%)。最主要的是皮肤过敏反应(占34.93%),最严重的是过敏性休克(占21.24%),其他不良反应34例(23.29%)。其不良反应在多种稀释液中都能发生。结论:复方丹参注射液的主要不良反应是速发型变态反应,应合理使用,加强用药监护。
Objective:To analyse and discuss ADRs related to compound danshen injection.Methods:Literature survey was based on the CMCC of 1994～2004.Results:132 ADRs of 146 case taking compound danshen injection were reported,and more ADRs in male than in female.The occurrence of ADRs was commonly within two hours after injection.There were 11 allergic reactions(76.71%)and 34 other reactions(23.29%),the most type of the former being skin reactions(34.93%)and the serious type being anaphylactic shock(21.24%).The ADRs were likely to happen in any solvents.Conclusion:The ADRs was mostly fleetly allergy,and it is important to reinforce monitoring of compound danshen infection.
出处
《中国药物应用与监测》
CAS
2005年第2期29-31,共3页
Chinese Journal of Drug Application and Monitoring
