摘要
目的 探讨再普乐快速镇静疗法的临床疗效与安全性。方法 随机选取具有明显兴奋症状的分裂症患者11例和躁狂症患者1例,给予再普乐(15～25 mg/d)快速镇静治疗2周。以治疗前后简明精神病量表(BPRS)激越分的减分率评定疗效,以不良反应量表评定安全性。结果 1周后10例有效,2例无效,有效率83.3％。2周后11例有效,1例脱落,有效率91.7％。病人有体重增加等轻度副反应。结论 再普乐快速疗法疗效肯定,病人耐受性良好。
Objective: To observe the safety and efficacy of rapid control therapy with olanzapine. Methods: 11 schizophrenics and 1 maniac with excitation symptom were randomly selected. Olanzapine ( 15 -25 mg/d) were acutely administered for 2 weeks. Efficacy and safety of the treatment were assessed respectively by Brief Psychiatric Rating Scale (BPRS) and Treatment-emergent Signs and Symptoms (TESS). Results: After 1 week treatment, 10 cases were rated as effective while 2 were rated ineffective, the rate of effectiveness was 83. 3% ; at the end of 2 week, 11 patients were rated as effective and 1 dropped-out, the rate of effectiveness was 91.7%. Patients had some mild adverse effects such as weight gain. Conclusion: The results indicated that acute coutrol therapy with olanzapine had definite effectiveness with good tolerability.
出处
《上海精神医学》
北大核心
2003年第6期344-346,共3页
Shanghai Archives of Psychiatry
关键词
再普乐
快速镇静疗法
Olanzapine Rapid tranquilization
