摘要
正常肝脏肝窦壁Ⅳ型胶原和层连蛋白染色阳性,说明存在基底膜结构,是为功能性基底膜。肝硬化时肝窦毛细血管化,使功能性基底膜破坏。肝硬化时各种细胞外基质成分显著增多,以Ⅰ型胶原为最多。由于各成分增多程度不一致,使细胞外基质的构成发生了改变,原发性肝细胞性肝癌组织中细胞外基质的分布与含量与癌组织的分化程度密切相关,分化程度高,细胞外基质沿癌组织小梁间的血窦壁排列成连续或断续线状;分化程度低,癌组织的细胞外基质仅见于血管壁。
We studied the distribution of type Ⅰ, Ⅲ, Ⅳ, Ⅴ collagen and laminin by immunohistochemical staining on three groups including 5 normals, 50 patients with cirrhosis and 15 patients with hepatocellular carcinoma(HCC). The results showed that functional basement membrane presented in the normal sinusoids, and that normal components, of extracellular matrix(ECM) changed, and the capillarization of sinusoids destroyed the functional basement membrane. Among of the changes of components of ECM, type Ⅰ collagen in...
出处
《医学检验与临床》
2002年第3期9-10,共2页
Medical Laboratory Science and Clinics
关键词
细胞外基质
肝硬化
原发性肝细胞性肝癌
Extracellular matrix
Liver cirrhosis
Hepatocellular carcinoma
