摘要
目的分析幽门螺旋杆菌(HP)感染时血清及胃黏膜组织中白细胞介素(IL-8)和肿瘤坏死因子(TNF)-α的水平,探讨它们之间的关系。方法采用放射免疫法和酶联免疫吸附实验夹心法分别检测了HP阳性患者在治疗前后,血清和胃黏膜组织中的IL-8、TNF-α的水平。结果幽门螺旋杆菌感染程度越严重者,胃黏膜组织中IL-8、TNF-α水平越高,各组间差异均有显著意义(P<0.05)。HP根除后血清、胃黏膜组织中IL-8、TNF-α水平水平明显下降,与根除前相比有显著性差异(P<0.05)。结论IL-8、TNF-α与HP感染密切相关,且参与了胃黏膜损伤的病理过程。
Objective To evaluate the relation between Helicobacter pyloi (HP)infection and IL-6 and TNF-α in serum and gastric mucosa.Method Radio-immunity and ELISA sandwith. were used to detective IL-6 and TNF-α in Hp infestation before and after eradication.Result The high extend of Hp infestation,the more activity of IL-6 and TNF-α.There are show great difference among them(P<0.05).The level of IL-6 and TNF-α in serum and gastric mucosa.were obviousely decreased in Hp infestation before and after eradicatian(P < 0. 05) . Conclusion IL - 6、TNF -αwere closely associated with Hp infestation. They play a significant role in mucosal injury.
出处
《医学检验与临床》
2008年第5期44-46,63,共3页
Medical Laboratory Science and Clinics
