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轻度认知功能障碍老年人和阿尔茨海默病患者听觉事件相关电位 P_(300)比较 被引量:1

Comparison of P_(300) Between Patients with Mild Cognitive Impairment and Patients with Alzheimer Disease
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摘要 目的探讨轻度认知功能障碍老年人(MCI)和阿尔茨海默病(AD)在事件相关电位(ERP)P_(300)检测中的不同表现。方法收集符合 ICD-10诊断标准的36例 MCI 患者和30例 AD,并以45例健康老人作对照组(NC)。使用美国仪器以及"听觉靶—非靶刺激序列"为诱发事件,完成 P_(300)检测。结果(1)3组和 NC 组在靶潜伏期 Fz 脑区 N_2以及在靶波幅 F_z 恼区 P_2P_3和非靶波幅 Fz 脑区 P_2上均有显著差异(P<0.01)。(2)AD 主成分 N_2表现为延迟,与 NC 组和 MCI 组有极显著性差异(P<0.01)。(3)MCI 组和 AD 组靶波幅 P_3和非靶波幅 P_2均见降低,与 NC 组比较也有显著性差异(P<0.05~<0.01)。结论提示作为反映 MCI 和 AD 认知功能障碍的客观生理指标,P_(300)有可能作为 MCI 和 AD 辅助诊断的一个脑电生理学标志。P_(300)检查可作为老年精神科的必查项目。 Objective To investigate the changes of event-related potentials P_(300)in patients with mild cognitive impairment and Alzheimer disease(AD).Methods An'oddball'paradigm was used to elicit the auditorv P_(300) from 36 patients diagnosed as having MCI according to ICD-10,30 patients with AD and 45 normally age-matched controls,by using a Nicolet.Bravo Instrument.Results A significant difference of ERP-P_(300)among 3 subject groups was found in both latencies(Fz/N_Z)and amplitudes(F_z/P_3,Fz/P_2)(P<0.01).Compared with NC and MCI groups,AD group showed prolonged latency(P<0.01)and decreased amplitude(P<0.01).Compared with NC groups,MCI and AD patients showed decreased P_3amplitude from target and P_2amplitude from nontarget(P< 0.05 or<0.01).Conclusion Auditory P_(300)ERP can serve as a physiological index in the accessory diagnosis of the cognitive disorder in MCI and AD.
出处 《神经病学与神经康复学杂志》 2005年第1期18-20,36,共4页 Journal of Neurology and Neurorehabilitation
关键词 轻度认知功能障碍老年人 阿尔茨海默病 事件相关电位P300 mild cognitive impairment Alzheimer disease ovent-related potentials P_(300)
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  • 1肖世富,陈兴时,薛海波,李冠军,张明园.老年轻度认知功能损害的脑诱发电位变化及其发展为痴呆的预测因素[J].老年医学与保健,2005,11(4):219-222. 被引量:4
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  • 8Bennys K, PorteI F, Touchon J, et al. Diagnostic value of event-related evoked potentials N200 and P300 subcompo nents in early diagnosis of Alzheimer's disease and mild cog nitive imPairment[J]. J Clin Nenrophysiol, 2007,24 (5) : 405 -412.
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  • 10刘宏亮,余洪俊.P300电位的原理和临床应用[J].中国临床康复,2002,6(21):3195-3196. 被引量:19

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