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S100A6蛋白在甲状腺癌中的表达及意义 被引量：2

Expression of S100A6 Protein in Thyroid Cancer and its Significance
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摘要 [目的]探讨S100A6蛋白在甲状腺癌中的表达及临床意义。[方法]应用免疫组织化学法检测108例甲状腺石蜡标本中S100A6蛋白表达情况,其中甲状腺癌57例(乳头状癌43例,滤泡状癌14例),甲状腺滤泡型腺瘤15例,癌旁甲状腺组织36例。[结果]S100A6蛋白在甲状腺癌、甲状腺滤泡型腺瘤及癌旁正常甲状腺组织中的阳性表达率分别为82.5%(47/57)、40.0%(6/15)和16.7%(6/36),三组比较差异有统计学意义(P<0.01)。乳头状癌、滤泡状癌中S100A6蛋白的阳性表达率分别为97.7%(42/43)、35.7%(5/14),乳头状癌组织中S100A6蛋白的阳性表达率显著高于滤泡状癌(P<0.01)。[结论]S100A6蛋白在甲状腺癌组织中过表达,不同病理类型甲状腺癌组织S100A6蛋白表达水平不同。S100A6有望成为甲状腺癌的早期诊断和鉴别诊断标志物之一。
作者 苏影 张谷 潘超 倪型灏
机构地区 浙江省肿瘤医院
出处 《肿瘤学杂志》 CAS 2009年第10期908-910,共3页 Journal of Chinese Oncology
关键词 S100A6蛋白 甲状腺肿瘤 免疫组织化学
分类号 R736.1 [医药卫生—肿瘤]
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参考文献10

  • 1Króliczak W,,Pietrzak M,Puzianowska-Kuznicka M.p53-dependent suppression of the human calcyclin gene(S100A6):the role of Sp1and of NFkappaB[].Acta Biochimica Polonica.2008
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同被引文献56

  • 1迮仁浩,杨述华,李进.人骨肉瘤中S100A6蛋白的表达及其意义[J].临床骨科杂志,2007,10(1):64-66. 被引量：2
  • 2Xiaoji Luo MD, PhD,Katie A. Sharff BA,Jin Chen MD,Tong-Chuan He MD, PhD,Hue H. Luu MD.S100A6 Expression and Function in Human Osteosarcoma[J]. Clinical Orthopaedics and Related Research . 2008 (9)
  • 3Lesniak W,Szczepanska A,Kuznicki J,et al.Calcylin(S100A6)expression is stimulated by agents evoking oxidative stress viathe antioxidant response element. Biochemistry and Biophysics . 2005
  • 4Joung H J,Jae W K,Younghee L,et al.Involvement of NFκ-βin the regulation of S100A6 gene expression in human hepato-blastoma cell line HepG. Biochemical and Biophysical Research Communications . 2003
  • 5Vimalachandran D,Greenhalf W,Thompson C,et al.Highnuclear S100A6 is significantly associated with poor survivalin pancreatic cancer patients. Cancer Research . 2005
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  • 8Melle C,Ernst G,Schimmel B,et al.Colon-derived liver me-tastasis,colorectal carcinoma,and hepatocellular carcinomacan be discriminated by the Ca(+2)-binding proteins S100A6and S100A11. PLoS One . 2008
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  • 10Ferrero S,Gillott D J,Kemorgida V,et al.Peritoneal fluid pro-teome in women with different ASRM stages of endometrosis. Gynecological Endocrinology . 2008

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肿瘤学杂志
2009年 第10期

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