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紫杉醇联合卡培他滨二线治疗晚期胃癌38例

Combination of Paclitaxel and Capecitabine as Second-line Chemotherapy in the Treatment of 38 Cases with Advanced Gastric Cancer
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摘要 [目的]评价紫杉醇联合卡培他滨二线治疗晚期胃癌的疗效及安全性。[方法]经病理证实的进展期胃癌患者38例,紫杉醇160~175mg/m2静脉滴注3h,d1;联合卡培他滨1250mg/m2,口服,2次/d,d1~14,服用2周后休息1周;21d为1个周期。[结果]36例可评价疗效患者,PR9例,有效率为23.7%(95%CI:10.2%~37.2%)。中位TTP和OS分别为4.4(95%CI:3.4~5.4)个月和7.2(95%CI:6.6~12.1)个月。Ⅲ/Ⅳ度毒副反应主要为骨髓抑制、手足综合征及脱发。[结论]紫杉醇联合卡培他滨方案二线治疗晚期胃癌疗效确切,毒副作用小。
出处 《肿瘤学杂志》 CAS 2009年第10期931-933,共3页 Journal of Chinese Oncology
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