期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CD4^+ CD25^+调节性T细胞与恶性腹水的相关研究进展

Research advances of CD4^+ CD25^+ regulatory T cells in malignant ascites
下载PDF
导出
摘要 CD4+ CD25+调节性T细胞(CD4+ CD25+Treg细胞)是具有独特免疫调节功能的T细胞亚群,抑制免疫反应,在机体免疫稳态维持、肿瘤免疫及移植耐受等方面发挥重要的作用。近年来,调节性T细胞在肿瘤免疫及治疗的研究中受到越来越广泛的关注。现就调节性T细胞在恶性腹水方面的研究做一简要综述。 CD4+CD25+regulatory T cells(CD4+CD25+Treg cells) take unique regulatory function in immune system by inhibiting the immune response.They play important roles in the maintenance of immune homeostasis,tumor immunity and tumor transplantation tolerance.This article makes a summary on its research progress of of CD4+ CD25+ regulatory T cells in malignant ascites.
作者 严波 燕善军
机构地区 蚌埠医学院第一附属医院消化内科
出处 《胃肠病学和肝病学杂志》 CAS 2009年第11期1059-1061,共3页 Chinese Journal of Gastroenterology and Hepatology
关键词 CD4+ CD25+调节性T细胞 恶性腹水 肿瘤免疫 肿瘤治疗 CD4+ CD25+ regulatory T cells Malignant ascites Tumor immunity Tumor treatment
分类号 R730.3 [医药卫生—肿瘤]
  • 相关文献

参考文献10

  • 1Bamias A,Tsiatas ML,Kafantari E,et al.Significant differences oflymphocytes isolated from ascites of patients with ovarian cancer com-pared to blood and tumor lymphocytes.Association of CD3+CD56+cells with platinum resistance[].Gynecologic Oncology.2007
  • 2Sakaguchi S,Sakaguchi N,Asano M,et al.Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases[].Journal of Immunology.1995
  • 3Khattri R,Cox T,Yasayko SA,et al.An essential role for Scurfin in CD4+CD25+ T regulatory cells[].Nature Immunology.2003
  • 4Cosmi L,Liotta F,Lazzeri E,et al.Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes[].Blood.2003
  • 5Walker MR,Kasprowicz DJ,Gersuk VH,et al.Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25-T cells[].The Journal of Clinical Investigation.2003
  • 6Roncarolo M G,Bacchetta R,Bordignon C,et al.Type 1 T regulatory cells[].Immunological Reviews.2001
  • 7Shevach E M,McHugh R S,Piccirillo C A,et al.Control of T-cell activation by CD4~+CD25~+ suppressor T cells[].Immunological Reviews.2001
  • 8Nakamura K,Kitani A,Strober W.Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta[].The Journal of Experimental Medicine.2001
  • 9Cureil TJ,Coukos G,Zou L,et al.Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival[].Nature Medicine.2004
  • 10GJ Betts,SL Clarke,HE Richards,AJ Godkin,AM Gallimore.Regulating the immune response to tumours[].Advanced Drug Delivery Reviews.2006
胃肠病学和肝病学杂志
2009年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部