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Alcohol,inflammation,and gut-liver-brain interactions in tissue damage and disease development 被引量:27

Alcohol,inflammation,and gut-liver-brain interactions in tissue damage and disease development
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摘要 Chronic inflammation is often associated with alcoholrelated medical conditions. The key inducer of such inflammation, and also the best understood, is gut microflora-derived lipopolysaccharide (LPS). Alcohol can significantly increase the translocation of LPS from the gut. In healthy individuals, the adverse effects of LPS are kept in check by the actions and interactions of multiple organs. The liver plays a central role in detoxifying LPS and producing a balanced cytokine milieu. The central nervous system contributes to anti-inflammatory regulation through neuroimmunoendocrine actions. Chronic alcohol use impairs not only gut and liver functions, but also multi-organ interactions, leading to persistent systemic inflammation and ultimately, to organ damage. The study of these interactions may provide potential new targets for therapeutic intervention. Chronic inflammation is often associated with alcoholrelated medical conditions. The key inducer of such inflammation, and also the best understood, is gut microflora-derived lipopolysaccharide (LPS). Alcohol can significantly increase the translocation of LPS from the gut. In healthy individuals, the adverse effects of LPS are kept in check by the actions and interactions of multiple organs. The liver plays a central role in detoxifying LPS and producing a balanced cytokine milieu. The central nervous syst...
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第11期1304-1313,共10页 世界胃肠病学杂志(英文版)
关键词 Chronic alcohol use Chronic inflammation Li- popolysaccharides Pro-inflammatory and anti-inflammatory cytokines Kupffer cells MONOCYTES Tumor necrosis factor α INTERLEUKIN-10 NEUROENDOCRINE Hypothalamo-pituitary-adrenal axis GLUCOCORTICOID Chronic alcohol use Chronic inflammation Li- popolysaccharides Pro-inflammatory and anti-inflammatory cytokines Kupffer cells Monocytes Tumor necrosis factor α Interleukin-10 Neuroendocrine Hypothalamo-pituitary-adrenal axis Glucocorticoid
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