摘要
目的观察替罗非班对高危非ST段抬高型心肌梗死(non-ST-elevation myocardial infarction,NSTEMI)患者急诊经皮冠状动脉介入(percutaneaus coronary intervention,PCI)治疗后左心室功能及内皮功能的影响,进而探讨其作用机制。方法100例高危NSTEMI患者随机分为两组,实验组50例,PCI治疗前给予替罗非班,对照组50例未给予替罗非班。观察PCI治疗前、后心肌梗死溶栓(thrombolysis in myocardial infarction,TIMI)血流情况及主要心血管事件,PCI治疗后第7天及第90天测定左心室功能和内皮依赖性舒张功能等指标。结果实验组PCI治疗后等容舒张时间和主要心血管事件发生率显著低于同期对照组,差异有统计学意义(P<0.05),TIMI血流3级率、E/A、左心室射血分数和内皮依赖性舒张功能显著高于同期对照组,差异有统计学意义(P<0.05)。结论替罗非班可增加高危NSTEMI急诊PCI治疗后梗死相关动脉血流,改善左心室功能及内皮功能,并降低主要心血管事件的发生率。
Objectives To investigate the effects of tirofiban on left ventricular function and endothelial function after percutaneous coronary intervention(PCI)in patients with high-risk non-ST-elevation myocardial infarction(NSTEMI) and evaluate mechanism of tirofiban.Methods One hundred high-risk NSTEMI patients were randomly divided into two groups.Experimental group(50 cases) were treated with tirofiban before PCI,and control group(50 cases) were treated without tirofiban.Basic clinical information and angiograph...
出处
《岭南心血管病杂志》
2009年第6期464-466,共3页
South China Journal of Cardiovascular Diseases
关键词
心肌梗死
血管成形术
经腔
经皮冠状动脉
心室功能
左
内皮
替罗非班
myocardial infarction
percutaneous coronary intervention
left ventricular function
endothelial
tirofiban
