摘要
熊果酸属于五环三萜类化合物,广泛存在于天然植物中,具有多种显著的药理活性。近年来越来越多的科学家对其进行结构改造以得到高活性化合物,例如对C-3位、C12-C13双键或对C-28位的修饰。本文综述了近年来熊果酸的化学结构修饰与构效关系研究进展。
Ursolic acid,a pentacyclic triterpene compound,naturally occurs in a large variety of plants,has attracted considerable interest owing to its significant biological activities.In recent years,more and more scientists have been working on the structural modification at the C-3 position,C12-C13 double bond or C-28 position of ursolic acid in order to improve their biological activities.Herein a brief introduction of the recent progresses on the chemical structural modification and the structure-activity relat...
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2009年第6期580-584,共5页
Journal of China Pharmaceutical University
关键词
熊果酸
化学结构修饰
构效关系
ursolic acid
chemical structural modification
structure-activity relationship
