摘要
目的:制备静脉给药肿节风挥发油亚微乳。方法:采用高压乳匀法制备肿节风挥发油亚微乳,以离心稳定性参数、外观、pH作为评价指标,通过单因素考察和正交设计试验对处方和工艺进行了优化。结果:在优化处方及工艺条件下,所制备的肿节风挥发油亚微乳的平均粒径为164~169 nm,分散系数0.084~0.107,Zeta电位为-40 mV,稳定性良好。结论:该处方及工艺可行。
Objective:To prepare the submicron emulsion of fresh Zhongjiefeng volatile oil.Method:The Zhongjiefeng volatile oil submicron emulsion was obtained after passing the elementary emulsion through a high pressure homogenizer.The physical and chemical stability of the emulsion was evaluated with the stability parameter of centrifugation,appearance of emulsion and the pH.The formulation and processing factors were optimized by single factor reviewing and orthogonal experimental design.Result:By controlling vario...
出处
《中国中药杂志》
CAS
CSCD
北大核心
2009年第24期3199-3202,共4页
China Journal of Chinese Materia Medica
基金
浙江省重大科技攻关(2004C13009)
关键词
鲜肿节风挥发油
亚微乳
高压乳匀
Zhongjiefeng volatile oil
submicron emulsion
high pressure homogenization.
