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AKT2及磷酸化AKT2在非小细胞肺癌中的表达及临床意义 被引量:10

The Expression and Clinical Significance of AKT2,Phosphorylated AKT2 in Non-small Cell Lung Cancer
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摘要 目的研究AKT2及磷酸化AKT2(p-AKT2)在非小细胞肺癌(NSCLC)组织中的表达及临床意义。方法应用免疫组织化学法检测137例非小细胞肺癌组织中AKT2和p-AKT2表达,分析AKT2及p-AKT2表达与肺癌预后的关系。结果非小细胞肺癌组织中AKT2在腺癌及鳞癌组织中的阳性表达率分别为60.5%和54.1%,差异无统计学意义(P>0.05);p-AKT2在腺癌及鳞癌组织中的阳性表达率分别为68.4%和47.5%,差异有统计学意义(P<0.05)。同时,本研究发现AKT2和p-AKT2的表达在患者的年龄、性别、肿瘤TNM分期及细胞分化程度等方面差异无统计学意义(P>0.05)。生存分析显示,AKT2表达阳性的NSCLC患者5年生存率及中位生存时间与阴性表达者比较差异无统计学意义〔36%vs.30%,(33.960±2.485)月vs.(31.338±2.868)月,P>0.05〕;而p-AKT2表达阳性的患者5年生存率及中位生存时间与阴性表达者比较差异有统计学意义〔20%vs.56%,(28.464±2.235)月vs.(39.214±3.075)月,P<0.05〕。进一步分层分析发现,Ⅰ期NSCLC患者中,AKT2表达阳性者5年中位生存时间与阴性表达者比较差异无统计学意义〔(34.778±4.469)月vs.(40.133±5.632)月,P>0.05〕;而p-AKT2表达阳性的NSCLC患者5年中位生存时间与阴性表达者比较差异有统计学意义〔(29.808±4.337)月vs.(47.875±4.852)月,P<0.05〕。结论 p-AKT2在肺腺癌中的表达高于肺鳞癌,且p-AKT2的阳性表达缩短了NSCLC患者的5年中位生存时间。 Objective To study the expression and clinical significance of AKT2,phosphorylated AKT2(p-AKT2) in non-small cell lung cancer(NSCLC).Methods The tumor tissues were obtained from 137 cases of NSCLC,the expressions of AKT2 and p-AKT2 in the tissues were measured by immunohistochemistry.The statistic analysis was carried on to study the correlation of AKT2,p-AKT2 expression to the type of lung cancer,TNM stage,pathological grading.Survival analysis was also studied.Results The positive rates of AKT2 in lung adenocarcinoma and squamous carcinoma were 60.5% and 54.1% respectively(P>0.05).While the positive rates of p-AKT2 in lung adenocarcinoma and squamous carcinoma were 68.4% and 47.5%(P<0.05).The expressions of AKT2 and p-AKT2 were not correlated with age,gender,TNM stage and cell differentiation degree.Further more,survival analysis revealed that 5-year survival rate and median survival time for the patients with positive expression of p-AKT2 were significantly poorer than those with negative expression(20% vs 56%,(28.464±2.235) months vs(39.214±3.075) months,P<0.05),while there were no significant differences with regard to AKT2 expression.Conclsuion The positive expression of p-AKT2 in lung adenocarcinoma was higher than that in lung sqamous carcinomas.p-AKT2 may be a prognostic factor for non-small cell lung cancer.
出处 《四川大学学报(医学版)》 CAS CSCD 北大核心 2010年第4期586-589,共4页 Journal of Sichuan University(Medical Sciences)
关键词 AKT2 磷酸化AKT2 非小细胞肺癌 AKT2 p-AKT2 Non-small cell lung cancer
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  • 1Watanabe S, Oda M, Tsunezuka Y, et al. Peripheral small-sized (2 cm or less) non-small cell lung cancer with mediastinal lymph node metastasis:clinicopathologic features and patterns of nodal spread.Eur J Cardiothorac Surg,2002,22(6) : 995-999.
  • 2Watanabe S, Oda M, Go T, et al. Should mediastinal nodal dissection be routinely undertaken in patients with peripheral small-sized(2 cm or less) lung cancer? Retrospective analysis of 225 patients.Eur J Cardiothorac Surg,2001,20(5):1007-1011.
  • 3Takizawa T, Terashima M, Koike T, et al. Lymph node metastasis in small peripheral adenocarcinoma of the lung. J Thorac Cardiovasc Surg,1998,116(2) : 276-280.
  • 4Takamochi K, Nagai K, Suzuki K, et al. Clinical predictors of N2 disease in non-small cell lung cancer. Chest,2000,117(6) : 1577-1582.
  • 5Suzuki K. Nagai K, Yoshida J, et al. Clinical predictors of N2 disease in the setting of a negative computed tomographic scan in patients with lung cancer. J Thorac Cardiovasc Surg, 1999,117(3) :593-598.
  • 6Veronika FEZ, Margit D, Alexandar T, et al. Prognostic and diagnostic relevance of hnRNP A2/B1, hnRNP B1 and S100 A2 in non-small cell lung cancer. Cancer Detection and Prevention, 2006 , 30 (5) : 395-402.
  • 7Jian MT, Quan YH, Guo RX, et al. Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis. Lung Cancer, 2006 . 51 (2) : 181-191.
  • 8Sueoka E, Sueoka N, Goto Y, et al. Heterogeneous nuclear ribonucleoprotein B1 as early cancer biomarker for occult cancer of human lungs and bronchial dysplasia. Cancer Res, 2001,61: 1896-1902.
  • 9Snead DR, Perunovic B, Cullen N, et al. hnRNP B1 expression in benign and malignant lung disease. J Athology,2003;200(1) : 88-94.
  • 10Matsuyama S, Goto Y, Sueoka N, et al. Heterogeneous nuclear ribonucleoprotein B1 expressed in esophageal squamous cell carcinomas as a new biomarker for diagnosis. Jpn J Cancer Res, 2000;91(6) :658-663.

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