摘要
最近的研究显示,过氧化物酶体增殖物激活受体(PPARs)可以通过肾素-血管紧张素-醛固酮系统(RAAS)调节血压。在临床PPARs激动剂已开始使用,并且显示出很好的疗效和安全性。中药对RAAS的转录调控的研究也在兴起,已经获得了一定成就。本文就PPARs和中药对RAAS的转录调控作用以做一简单综述。
Recent research has revealed roles of the peroxisome proliferator activated receptor (PPAR) family of transcription factors in regulation of blood pressure. PPARα and PPARγ modulate the renin-angiotensin-aldosterone system (RAAS). RAAS is an important therapeutic target in hypertension. Herbs on the blockade of transcriptional regulation of RAAS are also promising, which has gained some achievements. This review summarizes current knowledge on the role of PPARs and herbs in the transcriptional control of th...
出处
《中国分子心脏病学杂志》
CAS
2011年第2期124-127,共4页
Molecular Cardiology of China
基金
天津市应用基础及前沿技术研究计划(天津市自然科学基金)"中药干预肝阳上亢型高血压不同模型物质基础变化的机理"研究项目的资助(课题号09JCZDJC20600)
