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胃癌相关血清标志物的临床意义及研究进展 被引量：6

Clinical value and research advances of serum tumor markers in gastric cancer
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摘要 胃癌是我国最常见的消化道恶性肿瘤之一,早期诊断、早期治疗是提高患者生存期及降低病死率的关键。血清肿瘤标志物检测具有无创、标准化等特点,是近年来众多学者研究的热点。该文针对基因与蛋白水平中近期研究较多的4种胃癌相关的血清标志物(E-cadherin、Runx3、hGC-1和VEGF家族的三个亚型)作一综述,并分析其对于诊断早期胃癌、监测病情变化及判断预后的应用价值。 Gastric carcinogenesis is one of the most commonly occurring malignant neoplasms in China,and early diagnosis and treatment are crucial to improving the quality of life and reducing mortality rates for patients with gastric cancer.Serum-based detection methods allow for a standardized and non-invasive approach to monitoring progression of gastric cancer.We therefore summarize four serum-based biomarkers(E-cadherin,Runx3,hGC-1 and 3 subtypes of VEGF family) for gastric cancer,categorized into groups of genes and proteins,and evaluate their individual values in detecting gastric cancer,surveillance and evaluating prognosis of patients with gastric cancer.
作者 葛沁怡 胡梅洁
机构地区 上海交通大学医学院附属瑞金医院卢湾分院消化内科 上海交通大学医学院附属瑞金医院临床医学院
出处 《上海交通大学学报（医学版）》 CAS CSCD 北大核心 2011年第4期505-509,共5页 Journal of Shanghai Jiao tong University:Medical Science
关键词 胃癌 肿瘤标志物 血清 诊断 预后 DNA甲基化 gastric cancer biomarker serum diagnosis prognosis DNA methylation
分类号 R735.2 [医药卫生—肿瘤]
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参考文献7

二级参考文献151

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共引文献332

同被引文献77

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引证文献6

二级引证文献14

上海交通大学学报（医学版）
2011年 第4期

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