摘要
目的放疗是鼻咽癌(nasopharyngeal carcinoma,NPC)首选的治疗手段。近年来,调强放疗(intensity modulatedradiation therapy,IMRT)已应用于鼻咽癌的临床治疗。文中探讨3.0T MRI对鼻咽癌调强放疗疗效评价的应用价值。方法回顾性分析经病理检查证实的20例鼻咽癌患者调强放疗前后的MRI影像,比较放疗前后肿瘤大小、信号以及边界变化情况。结果 18例放疗后肿瘤病灶缩小,1例变化不明显,1例增大,与放疗前比较差异具有统计学意义(P<0.05)。放疗后弥散加权成像(diffusion-weighted imaging,DWI)信号减低,表观弥散系数(apparent diffusion cofficient,ADC)值增大,与放疗前比较差异具有统计学意义(P<0.05)。10例动态增强病例,放疗前后时间信号曲线最大斜率(maximum slope,MS)减低、对比剂达峰时间(time to peak,TTP)延长。8例颈部转移性淋巴结缩小,并发鼻旁窦炎症6例和乳突炎1例。结论 3.0T MRI可良好显示鼻咽癌放疗后变化,对IMRT的疗效评价具有一定意义。
Objective Radiotherapy is the first-choice treatment for nasophyngeal carcinoma(NPC),and recent years have witnessed the application of the intensity modulated radiation therapy(IMRT) to its treatment.This study was to evaluate 3.0T MRI in assessing the effect of IMRT on NPC.Methods We retrospectively analyzed the MRI characteristics of 20 NPC patients treated by IMRT,and compared the sizes,signals and margins of the lesions before and after the treatment.Results After IMRT,18 of the lesions decreased in size,1 showed no obvious change,and 1 increased in size,with significant differences from pretreatment(P<0.05);the signal intensity of diffusion-weighted imaging(DWI) significantly decreased,while the apparent diffusion coefficient(ADC) remarkably increased as compared with pretreatment(P<0.05).The maximum slope(MS) was reduced and the time to peak(TTP) prolonged in 10 cases of dynamic contrast-enchancement(DCE),metastatic lymph nodes became smaller in 8,paranasal sinusitis developed in 6,and mastoiditis in 1 after IMRT.Conclusion 3.0T MRI can desirably manifest the changes in NPC after radiotherapy,and can be applied to the evaluation of the results of IMRT.
出处
《医学研究生学报》
CAS
2011年第6期602-606,共5页
Journal of Medical Postgraduates
关键词
鼻咽癌
调强放疗
磁共振
Nasopharyngeal carcinoma
Intensity modulated radiation therapy
Magnetic resonance imaging
