摘要
目的通过检测不同肥胖程度(肥胖、超重、正常体重)的轻、中、重度OSAHS患者及非OSAHS患者血浆神经肽Y(NPY)水平,探讨NPY与OSAHS之间的关系。方法选取2008年1月至2009年12月在东南大学附属中大医院睡眠呼吸监测中心接受多导睡眠图(PSG)监测的人群作为受试对象,检测其体重指数(BMI)和呼吸暂停低通气指数(AHI)等睡眠呼吸指标。采用酶联免疫法测定所有受试对象血浆NPY含量。比较不同严重程度和不同体重OSAHS患者血浆NPY水平差异。结果肥胖、超重及正常体重的中、重度OSAHS患者血浆NPY水平均显著高于相应体重非OSAHS受试者(P<0.05),而重度OSAHS患者的血浆NPY水平又高于轻、中度OSAHS患者(P<0.05)。不同严重程度的OSAHS患者及非OSAHS的受试对象中,仅肥胖的重度OSAHS患者血浆NPY水平显著高于超重的重度OSAHS患者(P<0.05),超重、正常体重的重度OSAHS患者间血浆NPY水平无显著差异;在中、轻度OSAHS患者及非OSAHS受试者中,肥胖、超重及正常体重受试者间血浆NPY水平无显著差异。OSAHS患者血浆NPY含量与AHI水平呈正相关(r=0.667,P<0.05),与BMI水平呈正相关(r=0.265,P<0.05),与最低血氧饱和度呈负相关(r=-0.523,P<0.05),与平均血氧饱和度呈负相关(r=-0.422,P<0.05),与颈围及腰臀比无显著相关性。结论 OSAHS患者的血浆NPY水平与OSAHS有关,且随着OSAHS严重程度加重而增加。OSAHS患者的血浆NPY水平与肥胖程度无关。
Objective To investigate the role of plasma neuropeptide Y(NPY) level in obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods The patients underwent polysomnography(PSG) monitoring in the sleep disorder center of Zhongda Hospital from January 2008 to December 2009 were analyzed.Plasma NPY levels were compared between different groups allocated according to apneahypopnea index(AHI) and body mass index(BMI).Plasma NPY levels were measured by enzyme-linked immunoassay.Results The plasma NPY levels in the severe and moderate OSAHS groups were significantly higher than the groups without OSAHS of the same weight degree(P<0.05).The plasma NPY levels in the severe OSAHS groups were significantly higher than the groups with mild and moderate OSAHS of the same weight degree.In the severe OSAHS patients,the plasma NPY level of the obese group was significantly higher than the overweight group and the normal weight group(P<0.05).In the non-OSAHS and mild to moderate OSAHS patients,there was no significant difference among different groups of weight(P>0.05).Plasma NPY level in the OSAHS patients was correlated positively with AHI(r=0.667,P<0.05) and BMI(r=0.265,P<0.05),but negatively with LSaO2(r=-0.523,P<0.05) and MSaO2(r=-0.422,P<0.05).Conclusion Plasma NPY level is correlated with OSAHS,and increases with the severity of OSAHS.Plasma NPY level has no correlation with obesity.
出处
《中国呼吸与危重监护杂志》
CAS
2011年第3期224-228,共5页
Chinese Journal of Respiratory and Critical Care Medicine
基金
江苏省自然科学基金(编号:bk2009277)
