摘要
目的探讨细菌感染是否是胆囊癌的危险因素。方法收集1995～2008年国外公开发表关于细菌感染与胆囊癌相关性的病例对照文献,利用Meta分析进行综合分析,通过计算合并优势比(OR值)进行评价。结果对所查文献进行评价筛选,共9篇文献入选,合计样本量922例,其中胆囊癌病例307例,对照组病例615例,经合并OR值,认为细菌感染是胆囊癌发病的因素之一(OR=3.28,95%CI2.28～4.72)。亚组分析中,沙门菌感染者OR值为3.31(95%CI2.26～4.86),螺杆菌感染者OR值为3.06(95%CI1.00～9.37)。结论感染特别是沙门菌感染可以认为是胆囊癌发病的危险因素之一。而螺杆菌可能是胆囊癌发病的协同因素。
Objective To explore the relationship between infections,especially Salmonella sp.and Helicobacter infection,and the incidence of gallbladder cancer.Methods We performed a meta-analysis of studies of the association between infections and risk of gallbladder cancer identified from MEDLINE,EMBASE and Pubmed databases from 1995 to 2008 and the references of retrieved articles.Results A random-effects model was used to combine results from fourteen case-control studies,with a total of 336 cases.The association with infections was strong(OR=3.28,95% CI 2.28-4.72).Compared with benign gallbladder disease(control group),the relative risk of gallbladder cancer for those who were Salmonella sp.infected or Helicobacter sp.infected,was 3.31 (95% CI 2.26-4.86) and 3.06(95% CI 1.00-9.37)respectively.There was no statistically significant heterogeneity among the results of individual studies.Conclusions This Meta-analysis confirms the association between infections and risk of gallbladder cancer.Especially,Salmonella sp.infection is a risk factor while Helicobacter sp.infection may be a co-factor.
出处
《中华临床医师杂志（电子版）》
CAS
2011年第6期1606-1610,共5页
Chinese Journal of Clinicians(Electronic Edition)
基金
2008嘉定区青年科研基金(QNKYJJ2008-11-02)
关键词
感染
胆囊肿瘤
危险因素
螺杆菌属
沙门菌属
Infection
Gallbladder neoplasms
Risk factors
Helicobacter
Salmonella
