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肿瘤恶病质的肌肉消耗 被引量:3

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摘要 恶病质(cachexia)是各种恶性肿瘤患者的主要并发症,晚期肿瘤患者约80%存在厌食和体重下降等,约20%肿瘤患者直接死于由恶病质引起的心肺功能衰竭[1],是影响患者生存质量和预后的主要因素。近年来研究结果提示肌肉消耗(muscle wasting)是引起和加剧恶病质的中心环节;其机制与泛素-蛋白酶体系统(ubiquitin proteasome system,UPS)启动,肌萎缩关键基因激活,引起蛋白质降解有关;涉及胰岛素受体后信号途径受损、
出处 《中华临床医师杂志(电子版)》 CAS 2011年第13期3873-3875,共3页 Chinese Journal of Clinicians(Electronic Edition)
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